Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
about
FTIR markers of methionine oxidation for early detection of oxidized protein therapeutics.The effects of excipients and particle engineering on the biophysical stability and aerosol performance of parathyroid hormone (1-34) prepared as a dry powder for inhalationAggregation of biopharmaceuticals in human plasma and human serum: implications for drug research and developmentImmunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice.Modifications of therapeutic proteins: challenges and prospects.Extrinsic fluorescent dyes as tools for protein characterizationApplication of flow field-flow fractionation for the characterization of macromolecules of biological interest: a review.Flow field-flow fractionation: recent trends in protein analysis.Size-Exclusion Chromatography for the Analysis of Protein Biotherapeutics and their AggregatesConformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding.Quality control and stability studies with the monoclonal antibody, trastuzumab: application of 1D- vs. 2D-gel electrophoresis.A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.Solubility evaluation of murine hybridoma antibodies.Validation of an automated method for compounding monoclonal antibody patient doses: case studies of Avastin (bevacizumab), Remicade (infliximab) and Herceptin (trastuzumab).Disaggregation of high-molecular weight species during downstream processing to recover functional monomer.Structure-based engineering of a monoclonal antibody for improved solubility.Temperature denaturation and aggregation of a multi-domain protein (IgG1) investigated with an array of complementary biophysical methods.The effect of formulation variables on protein stability and integrity of a model IgG4 monoclonal antibody and translation to formulation of a model ScFv.Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants.
P2860
Q30398538-478F31AF-961B-4308-B7D0-D481C3F7E42FQ33805046-EA67A8B3-6608-49DC-8CA7-1B931D5B19EBQ34212786-52254E17-D81C-4A57-BE93-4DB548E47BC5Q36411853-0D7EA4B1-0710-47C6-A05A-3540E33C431EQ36495973-DF21B465-E5B1-45B4-9DFD-44338A895D93Q36738230-6C565990-EEEF-402D-AFA9-01350CF4BB1FQ37801326-7A33D600-7E8E-493E-AD68-5109FF1ECDBDQ37806643-2744C332-A0E5-4434-8164-42C01D99C487Q38078925-706D4C24-CA2B-4907-A543-7E81B991376CQ39175704-E09BA1A4-4B7D-4DE5-B84B-6E4EA5D2944CQ39357941-911F61BE-A980-4307-8D02-8DC6E58A0735Q41603684-31D65BD2-77B8-40D5-97B1-BFB92E42B1C5Q42008413-BAFF2DD2-1AB2-400F-B9DF-FB7D8F1A7ED3Q43175879-81057574-847F-443F-A4A5-A97DFED85866Q43205927-1475F57D-5286-4B92-9ED1-DC06B9A6D287Q44381771-E7DA10BF-6B19-413B-9604-D1F4BEAB6FD8Q46870536-F69EABEC-882F-4080-8E0A-E631923187BEQ47757883-575B4390-86D6-468C-93F0-B6554B014DEFQ51730438-0BA4EEBD-EA1E-44C1-9EF3-1744764A6D5B
P2860
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@en
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@nl
type
label
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@en
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@nl
prefLabel
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@en
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@nl
P2093
P1476
Characterization of protein aggregation: the case of a therapeutic immunoglobulin.
@en
P2093
Alex F Drake
Barthélemy Demeule
M Jayne Lawrence
Robert Gurny
Tudor Arvinte
P304
P356
10.1016/J.BBAPAP.2006.10.010
P577
2006-10-27T00:00:00Z