Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.
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Innate immunity against Leishmania infectionsImpact of Leishmania metalloprotease GP63 on macrophage signalingDuplicated paralogous genes subject to positive selection in the genome of Trypanosoma bruceiLeishmania-specific surface antigens show sub-genus sequence variation and immune recognitionEffect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survivalMolecular and cellular characterization of an AT-hook protein from LeishmaniaInflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivoEvolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion.Transcriptome analysis of the Cryptocaryon irritans tomont stage identifies potential genes for the detection and control of cryptocaryonosis.Characterization of a subunit of the outer dynein arm docking complex necessary for correct flagellar assembly in Leishmania donovaniMajor surface protease of trypanosomatids: one size fits all?Identifying vaccine targets for anti-leishmanial vaccine developmentLeishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63.Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategiesLeishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology.Macrophage cytokines: involvement in immunity and infectious diseasesRole of sphingolipids in microbial pathogenesisDoes the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?Deception and manipulation: the arms of leishmania, a successful parasiteTrichonomas vaginalis metalloproteinase induces apoptosis of SiHa cells through disrupting the Mcl-1/Bim and Bcl-xL/Bim complexesThe oligopeptidase B of Leishmania regulates parasite enolase and immune evasion.Trichomonas vaginalis metalloproteinase induces mTOR cleavage of SiHa cells.Comparative in-silico genome analysis of Leishmania (Leishmania) donovani: A step towards its species specificity.The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity.PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection.Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species.Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania.Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity.gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection.Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63.Host-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Episomally driven antisense mRNA abrogates the hyperinducible expression and function of a unique cell surface class I nuclease in the primitive trypanosomatid parasite, Crithidia luciliae.Exosome Secretion by the Parasitic Protozoan Leishmania within the Sand Fly Midgut.Synthetic Peptides as Potential Antigens for Cutaneous Leishmaniosis Diagnosis.Leishmania major LACK antigen is required for efficient vertebrate parasitization.Characterization of an I-E-restricted, gp63-specific, CD4-T-cell clone from Leishmania major-resistant C3H mice that secretes type 2 cytokines and exacerbates infection with L. major.Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review].Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activationThe ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function.
P2860
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P2860
Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Targeted gene deletion in Leis ...... (GP63) as a virulence factor.
@en
Targeted gene deletion in Leishmania major identifies leishmanolysin
@nl
type
label
Targeted gene deletion in Leis ...... (GP63) as a virulence factor.
@en
Targeted gene deletion in Leishmania major identifies leishmanolysin
@nl
prefLabel
Targeted gene deletion in Leis ...... (GP63) as a virulence factor.
@en
Targeted gene deletion in Leishmania major identifies leishmanolysin
@nl
P2093
P1476
Targeted gene deletion in Leis ...... (GP63) as a virulence factor.
@en
P2093
Ben L Kelly
David L Sacks
Phalgun B Joshi
Shaden Kamhawi
W Robert McMaster
P356
10.1016/S0166-6851(01)00432-7
P577
2002-03-01T00:00:00Z