Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases.
about
Gene targeting, genome editing: from Dolly to editorsEngineering large animal models of human diseaseProduction of biallelic CMP-Neu5Ac hydroxylase knock-out pigsProduction of Mutated Porcine Embryos Using Zinc Finger Nucleases and a Reporter-based Cell Enrichment SystemReduced binding of human antibodies to cells from GGTA1/CMAH KO pigs.Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genesN-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens.Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNAErythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates.Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN).Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs.Xenotransplantation literature update, March-April 2013.Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals.Recent developments and clinical studies utilizing engineered zinc finger nuclease technology.The combinational use of CRISPR/Cas9-based gene editing and targeted toxin technology enables efficient biallelic knockout of the α-1,3-galactosyltransferase gene in porcine embryonic fibroblasts.Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer.Disruption of the myostatin gene in porcine primary fibroblasts and embryos using zinc-finger nucleases.Silencing the porcine iGb3s gene does not affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection.Production and Breeding of Transgenic Cloned Pigs Expressing Human CD73.Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate?Xenotransplantation: back to the future?Production of heterozygous alpha 1,3-galactosyltransferase (GGTA1) knock-out transgenic miniature pigs expressing human CD39.Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection.Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes.
P2860
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P2860
Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@en
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@nl
type
label
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@en
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@nl
prefLabel
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@en
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@nl
P2093
P1476
Biallelic knockout of the α-1, ...... s using zinc finger nucleases.
@en
P2093
A Joseph Tector
Christopher Burlak
Jose L Estrada
P304
P356
10.1016/J.JSS.2012.06.035
P577
2012-07-03T00:00:00Z