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beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4β-Arrestin-1 directly interacts with Gαs and regulates its functionTraditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive ImpairmentsAn Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase ActivityTargeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesisGeneration of neural progenitor cells by chemical cocktails and hypoxiaA tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets.ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.Nuclear actin and myosin I are required for RNA polymerase I transcription.Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits.Beta-arrestin-1 protein represses diet-induced obesity.Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma)A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation.Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology.β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ.Evoking plasmin for beta-amyloid clearance.Why cell reprogramming is functionally linked to aging?γ-Secretase Modulators and Inhibitors Induce Different Conformational Changes of Presenilin 1 Revealed by FLIM and FRET.Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodopsin.Differential neurotoxicity of etorphine-like opiates: lack of correlation with their ability to activate opiate receptors.Molecular characterization and functional expression of opioid receptor-like1 receptor.Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulationActivation of aryl hydrocarbon receptor (ahr) by tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming.Direct conversion of astrocytes into neuronal cells by drug cocktail.A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization.Functional expression of opioid receptor-like receptor and its endogenous specific agonist nociceptin/orphanin FQ during mouse embryogenesis.N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C.Attenuation of delta opioid receptor-mediated signaling by kainic acid in neural cells: involvement of protein kinase C and intracellular Ca2+.β-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo.The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease.Establishment of TUSMi003-A, an induced pluripotent stem cell (iPSC) line from a 62-year old Chinese Han patient with Alzheimer's disease with ApoE3/4 genetic background.Generation of a human induced pluripotent stem cell line from a 65-year old healthy female donor with Chinese Han genetic background.Generation of a human control PBMC derived iPS cell line TUSMi001-A from a healthy male donor of Han Chinese genetic background.Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice.NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death.
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description
researcher ORCID: 0000-0002-8862-0591
@en
name
Jian Zhao
@ast
Jian Zhao
@en
Jian Zhao
@es
Jian Zhao
@nl
Jian Zhao
@sl
type
label
Jian Zhao
@ast
Jian Zhao
@en
Jian Zhao
@es
Jian Zhao
@nl
Jian Zhao
@sl
prefLabel
Jian Zhao
@ast
Jian Zhao
@en
Jian Zhao
@es
Jian Zhao
@nl
Jian Zhao
@sl
P106
P1153
57191161891
P31
P496
0000-0002-8862-0591