A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1.
about
Drosophila as an In Vivo Model for Human Neurodegenerative DiseaseExpanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis.
P2860
A fly model for the CCUG-repeat expansion of myotonic dystrophy type 2 reveals a novel interaction with MBNL1.
description
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A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@en
A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@nl
type
label
A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@en
A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@nl
prefLabel
A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@en
A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@nl
P2093
P2860
P356
P1476
A fly model for the CCUG-repea ...... novel interaction with MBNL1.
@en
P2093
Lindsey D Goodman
Michelle Min
Nancy M Bonini
Shin-Yi Shieh
Xiuyin Teng
Yongqing Zhu
Zhenming Yu
P2860
P304
P356
10.1093/HMG/DDU507
P577
2014-10-09T00:00:00Z