Forced degradation of recombinant monoclonal antibodies: A practical guide.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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name

Forced degradation of recombinant monoclonal antibodies: A practical guide.

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Forced degradation of recombinant monoclonal antibodies: A practical guide.

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type

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label

Forced degradation of recombinant monoclonal antibodies: A practical guide.

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Forced degradation of recombinant monoclonal antibodies: A practical guide.

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prefLabel

Forced degradation of recombinant monoclonal antibodies: A practical guide.

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Forced degradation of recombinant monoclonal antibodies: A practical guide.

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P1476

Forced degradation of recombinant monoclonal antibodies: A practical guide.

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P2093

Alain Beck

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Alyssa Neill

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Amit Katiyar

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Bruce Mason

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Christine Nowak

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Gomathinayagam Ponniah

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Hongcheng Liu

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Jason K Cheung

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Joanne Sun

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Ram Bhat

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P2860

In vitro and in vivo modifications of recombinant and human IgG antibodies

Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping.

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody.

Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.

Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange.

Classification and characterization of therapeutic antibody aggregates.

Beta-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage.

Identification and quantification of degradations in the Asp-Asp motifs of a recombinant monoclonal antibody.

Separation and characterization of an IgG2 antibody containing a cyclic imide in CDR1 of light chain by hydrophobic interaction chromatography and mass spectrometry.

Strategies and challenges for the next generation of therapeutic antibodies.

P304

1217-1230

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scholarly article

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10.1080/19420862.2017.1368602

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2017-08-30T00:00:00Z

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28853987

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5680805

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