Proline-directed and non-proline-directed phosphorylation of PHF-tau. - Wikidata - awgldk - TriplyDB

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

http://www.wikidata.org/entity/Q53203171

about

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase Phosphorylation of microtubule-associated protein tau by AMPK-related kinases Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments NMR Meets Tau: Insights into Its Function and Pathology Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation Tau-tubulin kinase Physiological and pathological phosphorylation of tau by Cdk5 Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Tau and tauopathies Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Tau physiology and pathomechanisms in frontotemporal lobar degeneration Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro A novel tau-tubulin kinase from bovine brain Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein Structural polymorphism of 441-residue tau at single residue resolution Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39 Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain EDMAN SEQUENCING RESEARCH GROUP 2004 STUDY: MODIFIED AMINO ACIDS IN EDMAN SEQUENCING The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice.Sequencing of peptides phosphorylated on serines and threonines by post-source decay in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells.Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.Phosphorylation of tau is regulated by PKN.Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice.Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.REVIEW: tau protein pathology in Alzheimer's disease and related disorders.Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies.No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro.Acetylation: a new key to unlock tau's role in neurodegeneration Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.Mechanisms of tau-induced neurodegeneration.

P2860

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P2860

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

http://www.wikidata.org/entity/Q53203171

description

1995 nî lūn-bûn

@nan

1995年の論文

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1995年学术文章

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1995年学术文章

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1995年学术文章

@zh-cn

1995年学术文章

@zh-hans

1995年学术文章

@zh-my

1995年学术文章

@zh-sg

1995年學術文章

@yue

1995年學術文章

@zh-hant

name

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@en

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@nl

type

label

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@en

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@nl

prefLabel

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@en

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@nl

P1433

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P1476

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P1433

Journal of Biological Chemistry

P1476

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

@en

P2093

Hasegawa M

http://www.w3.org/2001/XMLSchema#string

Ihara Y

http://www.w3.org/2001/XMLSchema#string

Morishima-Kawashima M

http://www.w3.org/2001/XMLSchema#string

Suzuki M

http://www.w3.org/2001/XMLSchema#string

Takio K

http://www.w3.org/2001/XMLSchema#string

Titani K

http://www.w3.org/2001/XMLSchema#string

Yoshida H

http://www.w3.org/2001/XMLSchema#string

P2860

A protein factor essential for microtubule assembly

A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Protein kinase recognition sequence motifs

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

P304

823-829

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scholarly article

P356

10.1074/JBC.270.2.823

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P433

2

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P478

270

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232311457

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P698

7822317

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P921

phosphorylation