about
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymesEffect of combinations of antiviral drugs on herpes simplex encephalitis.Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivoAntivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosidesClostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compoundsBiochemical and functional characterization of Plasmodium falciparum DNA polymerase δN(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinasesSuper-telomeres in transformed human fibroblasts.Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.The effect of drugs on mitochondrial DNA synthesis can be tested in isolated synaptosomes.Prodrugs of herpes simplex thymidine kinase inhibitors.L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents.Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.Two-step genetic screening of thrombophilia by pyrosequencing.The control of cultural evolution has been tried, what's next?Maupertuis: the 'old synthesis'.Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutantsReplication of single-stranded porcine circovirus DNA by DNA polymerases alpha and deltaDo DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?A double-loop model for the replication of eukaryotic DNAAn enzymatic method for microdetermination of aphidicolin: a promising anticancer drugInhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilonNovel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Federico Focher
@ast
Federico Focher
@en
Federico Focher
@es
Federico Focher
@nl
Federico Focher
@sl
type
label
Federico Focher
@ast
Federico Focher
@en
Federico Focher
@es
Federico Focher
@nl
Federico Focher
@sl
prefLabel
Federico Focher
@ast
Federico Focher
@en
Federico Focher
@es
Federico Focher
@nl
Federico Focher
@sl
P106
P1153
7006348514
P21
P31
P496
0000-0002-0252-1518