A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer.
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Evolutionary Insights into RNA trans-Splicing in VertebratesHypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random PrimersTrop2 and its overexpression in cancers: regulation and clinical/therapeutic implicationsTrop-2 is a determinant of breast cancer survivalSeveral fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplificationCorrelation between Trop2 and amphiregulin coexpression and overall survival in gastric cancerTranscription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis?Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma.Long-range transcriptome sequencing reveals cancer cell growth regulatory chimeric mRNA.Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway.Uterine serous papillary carcinomas overexpress human trophoblast-cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized anti-Trop-2 monoclonal antibody.A unique four-hub protein cluster associates to glioblastoma progression.Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody.Trop-2 overexpression in poorly differentiated endometrial endometrioid carcinoma: implications for immunotherapy with hRS7, a humanized anti-trop-2 monoclonal antibody.Two RNAs or DNAs May Artificially Fuse Together at a Short Homologous Sequence (SHS) during Reverse Transcription or Polymerase Chain Reactions, and Thus Reporting an SHS-Containing Chimeric RNA Requires Extra Caution.TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.Prognostic value of TROP2 in human nasopharyngeal carcinoma.Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC).Landscape of gene fusions in epithelial cancers: seq and ye shall find.Aberrant MUC1-TRIM46-KRTCAP2 Chimeric RNAs in High-Grade Serous Ovarian Carcinoma.Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.Trop2 is overexpressed in gastric cancer and predicts poor prognosis.Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.Bioinformatics construction of the human cell surfaceome.Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target.Trop2 gene: a novel target for cervical cancer treatment.Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axisExpression of tumor-associated calcium signal transducer 2 in patients with salivary adenoid cystic carcinoma: Correlation with clinicopathological features and prognosis.Novel chimeric transcript RRM2-c2orf48 promotes metastasis in nasopharyngeal carcinoma.Long non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p.Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.Chimeric RNAs and their implications in cancer.TROP2 expression and its correlation with tumor proliferation and angiogenesis in human gliomas.Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma.The Trop-2 signalling network in cancer growth.TROP2 correlates with microvessel density and poor prognosis in hilar cholangiocarcinoma.Prognostic role and clinical significance of trophoblast cell surface antigen 2 in various carcinomas.Transcriptional-Readthrough RNAs Reflect the Phenomenon of "A Gene Contains Gene(s)" or "Gene(s) within a Gene" in the Human Genome, and Thus Are Not Chimeric RNAs.
P2860
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P2860
A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@en
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@nl
type
label
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@en
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@nl
prefLabel
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@en
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@nl
P2093
P50
P1433
P1476
A bicistronic CYCLIN D1-TROP2 ...... nic mechanism in human cancer.
@en
P2093
Barbara Palombo
Carlo Crescenzi
Cosmo Rossi
Franco Lorenzini
Giovanna Vacca
Roberta Dell' Arciprete
Tarek El-Sewedy
Tommaso Ciccimarra
Veronica Bonasera
P304
P356
10.1158/0008-5472.CAN-07-6135
P407
P577
2008-10-01T00:00:00Z