about
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionNuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent mannerBreastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriersCoding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAsA coding-independent function of gene and pseudogene mRNAs regulates tumour biologyApoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.Lats2/Kpm is required for embryonic development, proliferation control and genomic integrityRole of Pirh2 in mediating the regulation of p53 and c-Myc.Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.Requirement for caspase-8 in NF-kappaB activation by antigen receptor.A Role for PML in Innate ImmunitySubtle variations in Pten dose determine cancer susceptibilityNeuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicityCaspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityCaspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.Cellular FLICE-inhibitory protein is required for T cell survival and cyclingReduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specificHigh frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemiaPseudogene redux with new biological significance.Targeting mitochondrial RNA polymerase in acute myeloid leukemia.From photomorphogenesis to cancer: a CSN journey.Measurement of PTEN by Flow Cytometry.A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8.Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia.BRCA1 and BRCA2 mutations and breast cancer.SnapShot: PTEN signaling pathways.Phosphoinositide signaling in cancer: INPP4B Akt(s) out.Essential role for caspase-8 in Toll-like receptors and NFkappaB signalingChanging venues for tumour suppression: balancing destruction and localization by monoubiquitylationDistinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Leonardo Salmena
@ast
Leonardo Salmena
@en
Leonardo Salmena
@es
Leonardo Salmena
@nl
Leonardo Salmena
@sl
type
label
Leonardo Salmena
@ast
Leonardo Salmena
@en
Leonardo Salmena
@es
Leonardo Salmena
@nl
Leonardo Salmena
@sl
prefLabel
Leonardo Salmena
@ast
Leonardo Salmena
@en
Leonardo Salmena
@es
Leonardo Salmena
@nl
Leonardo Salmena
@sl
P106
P21
P31
P496
0000-0003-4023-658X