Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria.
about
Advances in understanding the pathogenesis of congenital erythropoietic porphyria.Missense UROS mutations causing congenital erythropoietic porphyria reduce UROS homeostasis that can be rescued by proteasome inhibition.Segment swapping aided the evolution of enzyme function: The case of uroporphyrinogen III synthase.A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R.Evolutionary Divergent Suppressor Mutations in Conformational DiseasesStructural basis of pyrrole polymerization in human porphobilinogen deaminase
P2860
Tuning intracellular homeostasis of human uroporphyrinogen III synthase by enzyme engineering at a single hotspot of congenital erythropoietic porphyria.
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name
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@en
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@nl
type
label
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@en
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@nl
prefLabel
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@en
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@nl
P2093
P2860
P50
P356
P1476
Tuning intracellular homeostas ...... ital erythropoietic porphyria.
@en
P2093
Arantza Sanz-Parra
Paula Pluta
P2860
P304
P356
10.1093/HMG/DDU298
P577
2014-06-12T00:00:00Z