The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus.
about
Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complexDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsHistone H3 lysine 56 acetylation and the response to DNA replication fork damageThe Epigenetic Pathways to Ribosomal DNA SilencingChoreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureCooperativity of the SUMO and Ubiquitin Pathways in Genome StabilityNucleolar responses to DNA double-strand breaksMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeSumoylation and transcription regulation at nuclear poresPerturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human diseaseMultiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNACharacterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse AnalysisGenome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.Regulation of ribosomal DNA amplification by the TOR pathway.The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase.PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.Role for perinuclear chromosome tethering in maintenance of genome stability.Condensin suppresses recombination and regulates double-strand break processing at the repetitive ribosomal DNA array to ensure proper chromosome segregation during meiosis in budding yeast.Reappearance from Obscurity: Mammalian Rad52 in Homologous RecombinationSUMO-mediated regulation of DNA damage repair and responsesThe SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stressRad52 sumoylation prevents the toxicity of unproductive Rad51 filaments independently of the anti-recombinase Srs2Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatidDouble-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.Role for rodent Smc6 in pericentromeric heterochromatin domains during spermatogonial differentiation and meiosis.In vivo modeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modificationLow levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae.Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Meiosis genes in Daphnia pulex and the role of parthenogenesis in genome evolution.Poetry in motion: Increased chromosomal mobility after DNA damage.Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombinationEssential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.Epigenetic regulation of heterochromatic DNA stability.Ribosomal DNA status inferred from DNA cloud assays and mass spectrometry identification of agarose-squeezed proteins interacting with chromatin (ASPIC-MS).SUMO Wrestles with RecombinationEmerging roles of chromatin in the maintenance of genome organization and function in plants.Timing is everything: cell cycle control of Rad52Epigenome Maintenance in Response to DNA DamageSUMOylation and de-SUMOylation in response to DNA damage.
P2860
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P2860
The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@en
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@nl
type
label
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@en
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@nl
prefLabel
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@en
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@nl
P2093
P2860
P356
P1433
P1476
The Smc5-Smc6 complex and SUMO ...... r at the ribosomal gene locus.
@en
P2093
Giacomo De Piccoli
Ivana Sunjevaric
Jordi Torres-Rosell
Luis Aragón
Meik Sacher
Nadine Eckert-Boulet
Robert Reid
Stefan Jentsch
P2860
P2888
P304
P356
10.1038/NCB1619
P577
2007-07-22T00:00:00Z