Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.

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Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors.Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors.

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Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.

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http://www.wikidata.org/entity/Q53564161

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年學術文章

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2016年學術文章

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name

Rational Design of a Boron-Mod ...... trogen Receptor Downregulator.

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Rational Design of a Boron-Modified Triphenylethylene

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type

Item

label

Rational Design of a Boron-Mod ...... trogen Receptor Downregulator.

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Rational Design of a Boron-Modified Triphenylethylene

@nl

prefLabel

Rational Design of a Boron-Mod ...... trogen Receptor Downregulator.

@en

Rational Design of a Boron-Modified Triphenylethylene

@nl

P1476

Rational Design of a Boron-Mod ...... trogen Receptor Downregulator.

@en

P2093

Changde Zhang

http://www.w3.org/2001/XMLSchema#string

Elena V Skripnikova

http://www.w3.org/2001/XMLSchema#string

Guangdi Wang

http://www.w3.org/2001/XMLSchema#string

Jiawang Liu

http://www.w3.org/2001/XMLSchema#string

Melyssa R Bratton

http://www.w3.org/2001/XMLSchema#string

Peng Ma

http://www.w3.org/2001/XMLSchema#string

Qiang Zhang

http://www.w3.org/2001/XMLSchema#string

Qiu Zhong

http://www.w3.org/2001/XMLSchema#string

Shanchun Guo

http://www.w3.org/2001/XMLSchema#string

Shilong Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Do

Comparative analyses of mechanistic differences among antiestrogens

Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen.

Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).

Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats.

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.

Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status.

P304

102-106

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scholarly article

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10.1021/ACSMEDCHEMLETT.6B00410

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2016-11-29T00:00:00Z

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28105283

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5238461

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Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.

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P2860

P2860

Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.

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type

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P1433

P1476

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