Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation.
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A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent CancersWnt Drug Discovery: Weaving Through the Screens, Patents and Clinical TrialsHexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutantsA ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.Ilimaquinone and ethylsmenoquinone, marine sponge metabolites, suppress the proliferation of multiple myeloma cells by down-regulating the level of β-catenin.Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.Postgenomic technologies targeting the Wnt signaling network.Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation.Small molecule-based promotion of PKCα-mediated β-catenin degradation suppresses the proliferation of CRT-positive cancer cells.Anchoring junctions as drug targets: role in contraceptive development.Small molecule modulators of Wnt/β-catenin signaling.Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway.Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cellsCytotoxic activity of rearranged drimane meroterpenoids against colon cancer cells via down-regulation of β-catenin expression.Wnt3a: functions and implications in cancer.Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail.Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1New approaches to molecular cancer therapeutics.Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator SiteA lignan induces lysosomal dependent degradation of FoxM1 protein to suppress β-catenin nuclear translocationWnt/beta-catenin signaling in glioma.Natural compounds with Wnt signal modulating activity.Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population.Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells.Anticancer effects of baicalein on hepatocellular carcinoma cells.Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.p53 Plays an important role in cell fate determination after exposure to microcystin-LR.Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice.DRUGSURV: a resource for repositioning of approved and experimental drugs in oncology based on patient survival information.Evaluation of anti-Wnt/β-catenin signaling agents by pGL4-TOP transfected stable cells with a luciferase reporter system.β-Sitosterol and flavonoids isolated from Bauhinia malabarica found during screening for Wnt signaling inhibitory activity.Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling.Smenospongidine suppresses the proliferation of multiple myeloma cells by promoting CCAAT/enhancer-binding protein homologous protein-mediated β-catenin degradation.Diarylheptanoids suppress proliferation of pancreatic cancer PANC-1 cells through modulating shh-Gli-FoxM1 pathway.Scaffold Diversity Synthesis Delivers Complex, Structurally, and Functionally Distinct Tetracyclic Benzopyrones.TFAP2 transcription factors are regulators of lipid droplet biogenesisSesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells
P2860
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P2860
Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Hexachlorophene inhibits Wnt/b ...... ated beta-catenin degradation.
@en
Hexachlorophene inhibits Wnt/b ...... ated beta-catenin degradation.
@nl
type
label
Hexachlorophene inhibits Wnt/b ...... ated beta-catenin degradation.
@en
Hexachlorophene inhibits Wnt/b ...... ated beta-catenin degradation.
@nl
prefLabel
Hexachlorophene inhibits Wnt/b ...... ated beta-catenin degradation.
@en
Hexachlorophene inhibits Wnt/b ...... ated beta-catenin degradation.
@nl
P2093
P356
P1476
Hexachlorophene inhibits Wnt/b ...... iated beta-catenin degradation
@en
P2093
Jae-Gook Shin
Jaejoon Won
Jungsug Gwak
Sangtaek Oh
Seoyoung Park
Taeyun Song
P304
P356
10.1124/MOL.106.024729
P50
P577
2006-05-30T00:00:00Z