Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.
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Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibodyAdvances in Antibody DesignIntrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity.Structural hot spots for the solubility of globular proteins.Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities.Antibody engineering for increased potency, breadth and half-life.Increased Fab thermoresistance via VH-targeted directed evolution.Construction of a Semisynthetic Human VH Single-Domain Antibody Library and Selection of Domain Antibodies against α-Crystalline of Mycobacterium tuberculosis.Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bondA polar ring endows improved specificity to an antibody fragment.Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies.Engineered Autonomous Human Variable DomainsComprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle.Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid PolypeptideRational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumabEnhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview.Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis.Improving the biophysical properties of anti-ricin single-domain antibodies.Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries.Overcoming low yields of plant-made antibodies by a protein engineering approach.Electrostatic engineering of the interface between heavy and light chains promotes antibody Fab fragment production.Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy.Molecular Modeling for Protein Aggregation and Formulation
P2860
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P2860
Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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2014年學術文章
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2014年學術文章
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name
Optimal charged mutations in t ...... dent on the antibody scaffold.
@en
Optimal charged mutations in t ...... dent on the antibody scaffold.
@nl
type
label
Optimal charged mutations in t ...... dent on the antibody scaffold.
@en
Optimal charged mutations in t ...... dent on the antibody scaffold.
@nl
prefLabel
Optimal charged mutations in t ...... dent on the antibody scaffold.
@en
Optimal charged mutations in t ...... dent on the antibody scaffold.
@nl
P2860
P356
P1476
Optimal charged mutations in t ...... dent on the antibody scaffold.
@en
P2093
Christine C Lee
Joseph M Perchiacca
P2860
P356
10.1093/PROTEIN/GZT058
P577
2014-01-06T00:00:00Z