about
The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.DNA oxidation profiles of copper phenanthrene chemical nucleases.Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmC 3-symmetric opioid scaffolds are pH-responsive DNA condensation agents.Triggering autophagic cell death with a di-manganese(II) developmental therapeuticProcess-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics.[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction.Regulating bioactivity of Cu2+ bis-1,10-phenanthroline artificial metallonucleases with sterically functionalized pendant carboxylates.Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+.Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2'-dipyridyl.Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and rBiological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands.Protein engineering with artificial chemical nucleases.Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells.Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity.Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate).Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.Copper phenanthrene oxidative chemical nucleases.Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination.Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity.Radical-induced purine lesion formation is dependent on DNA helical topology.A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavageWater-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug developmentInnovative DNA-Targeted Metallo-prodrug Strategy Combining Histone Deacetylase Inhibition with Oxidative StressBis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding propertiesFrontispiece: Polypyridyl‐Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical NucleasePolypyridyl‐Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical NucleaseSynthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogenDNA cleavage reactions of the dinuclear chemotherapeutic agent copper(II) bis-1,10- phenanthroline terephthalateIn-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexesCu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosisMolecular methods for assessment of non-covalent metallodrug-DNA interactionsCopper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor GrooveAssessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N'-dialkyl-9,9'-biacridylidenesEfficient DNA Condensation by a C3 -Symmetric Codeine ScaffoldA new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andrew Kellett
@ast
Andrew Kellett
@en
Andrew Kellett
@es
Andrew Kellett
@nl
Andrew Kellett
@sl
type
label
Andrew Kellett
@ast
Andrew Kellett
@en
Andrew Kellett
@es
Andrew Kellett
@nl
Andrew Kellett
@sl
prefLabel
Andrew Kellett
@ast
Andrew Kellett
@en
Andrew Kellett
@es
Andrew Kellett
@nl
Andrew Kellett
@sl
P106
P1153
12802144200
P21
P2798
P31
P496
0000-0002-8947-1401