Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.
about
AMPK and PPARdelta agonists are exercise mimeticsImpact of oxidative stress on exercising skeletal muscleInterplay between lipids and branched-chain amino acids in development of insulin resistanceAcylcarnitines: reflecting or inflicting insulin resistance?Regulatory roles for L-arginine in reducing white adipose tissueRedox regulation of mitochondrial functionActivity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese miceMetabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alphaPGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertensionChanges in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF ratsMetabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammationCalorie restriction increases muscle mitochondrial biogenesis in healthy humansGut microbiota from twins discordant for obesity modulate metabolism in miceIncreased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation.Decreased cytochrome c oxidase subunit VIIa in aged rat heart mitochondria: immunocytochemistry.Altered body composition and energy expenditure but normal glucose tolerance among humans with a long-chain fatty acid oxidation disorder.Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise.Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal musclePGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice.The effect of high glucocorticoid administration and food restriction on rodent skeletal muscle mitochondrial function and protein metabolismMetabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes.Skeletal Muscle Nucleo-Mitochondrial Crosstalk in Obesity and Type 2 Diabetes.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells.Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individualsSkeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity.Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traitsApelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice.PGC-1α and exercise in the control of body weight.Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patientsLipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpressionMetabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice.PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells.Metabolic profiling of muscle contraction in lean compared with obese rodents.Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans.Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.
P2860
Q24652674-C478B47C-9590-4FBB-814B-E728C6E644C2Q26825387-CDFE48DA-E44B-4FB8-80BC-CD5DF81E582DQ26852310-6C0979D1-2F1D-48D9-A2C4-B38069B821DDQ27004603-CBEF54C9-AB49-4791-B81A-571339E1F57EQ27021080-CFBED8E3-6EDE-419B-9141-87407D2B7EE4Q28383361-0695A2D7-E33D-4BC5-92B5-E93B78C12E21Q28484573-B735EF02-55A9-4588-A769-122BBF0E71DDQ28513388-4676A586-CB1A-458E-B179-2B6D23F0487AQ28578858-A11E4B99-53CF-4222-9452-9056CE282380Q28580733-32049A6B-B3FD-4024-BB4E-BE4F423A3F5FQ28728589-C72EFDCF-D6FE-4600-9740-EB52F10D960DQ28763406-90055B61-389E-4BC6-89BC-E4D7EF175431Q29614796-FCA81542-7F5F-408E-AE31-B6E1BB63F97FQ30356864-2F96B02B-4968-4A22-B870-6AFFB1F24165Q30407774-70DCB0A4-1B69-48EB-AE09-D7F3D96C28F1Q30409518-747AC09E-C603-4CAF-9D3D-2E436D01C0EEQ30422529-EB0F3DE8-246B-4BCC-BEDF-69828E112EFEQ30428955-3E687F45-03F4-4191-891E-7CDAB2B4DD2FQ30431199-E1133CFF-2084-4920-B072-8902254067B8Q33325905-75B42306-F44E-4A73-B794-175EEBC224ADQ33331801-E85FB91B-1A53-4641-A4E4-6F14A7D94774Q33432825-6740841C-50B5-466D-B921-D1F9E548EB10Q33549712-7A3E0D6C-E098-4C91-8EC9-2C4E2E665B56Q33624769-5A8B83D1-E6BE-4B57-A355-C8F66D6C3E99Q33668501-D384BCED-067B-43F9-B294-82D47A6B7D35Q33752866-69858BD7-A3C3-4FE7-8A7D-692F33A32CC5Q33779662-67C7B602-F2FE-4532-9496-2740EA16B795Q33861978-B7F3DFDB-59FC-421E-A5EA-E16220C95303Q33869768-84D17F60-FE34-4E5B-9251-FFCB843CA27CQ33950633-7E48C24C-CED0-48DC-8D6F-3543453A7C06Q33970039-20BAF739-B708-4C38-9CCE-958177966215Q34030044-1314B141-57ED-4962-9CD2-135548621977Q34030453-1700A088-0749-4D00-8186-4FBA22AB5BB3Q34061404-EA36EEFD-F974-49D4-99C6-3326FAC0673FQ34086699-CA268E7E-6101-42C0-9AA9-6F6CEC31EDD6Q34115288-915C9C48-4F74-41DB-90CC-EF99505C3445Q34137440-DD0B27E5-E82E-42AD-B069-D94D1CB8B869Q34150194-0EC4BF75-C89F-4DAC-84D2-515075E463CEQ34269093-2F85B738-BAD9-4B17-8943-708CD69E478CQ34276100-D662F432-B59B-4C05-9169-35C47A84581E
P2860
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@en
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@nl
type
label
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@en
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@nl
prefLabel
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@en
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@nl
P2093
P356
P1476
Peroxisome proliferator-activa ...... ed mitochondrial inefficiency.
@en
P2093
Christopher B Newgard
Dorothy Slentz
G Lynis Dohm
Olga Ilkayeva
Takayuki Akimoto
Timothy R Koves
P304
33588-33598
P356
10.1074/JBC.M507621200
P407
P577
2005-08-03T00:00:00Z