DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties.
about
Sodium/calcium exchange modulates intracellular calcium overload during posthypoxic reoxygenation in mammalian working myocardium. Evidence from aequorin-loaded ferret ventricular muscles.The effect of a new inotropic agent, DPI 201-106, on systolic time intervals and the electrocardiogram in healthy subjectsNa+ channels as sites of action of the cardioactive agent DPI 201-106 with agonist and antagonist enantiomers.Differential effect of DPI 201-106 on the sensitivity of the myofilaments to Ca2+ in intact and skinned trabeculae from control and myopathic human hearts.Role of intracellular sodium in the regulation of intracellular calcium and contractility. Effects of DPI 201-106 on excitation-contraction coupling in human ventricular myocardium.A comparative study of the cardiovascular and biochemical actions of the imidazo [4,5b] pyridine sulmazole and an imidazo [4,5c] pyridine analogue, BW A746CMechanisms of positive inotropic effects and delayed relaxation produced by DPI 201-106 in mammalian working myocardium: effects on intracellular calcium handling.Inotropic response to DPI 201-106 in the failing human heart.Antiarrhythmic effects of DPI 201-106.Sodium channel subconductance levels measured with a new variance-mean analysisThe cardiac sodium channel: a target for antiarrhythmic drug action.Properties of the block of single Na+ channels in guinea-pig ventricular myocytes by the local anaesthetic penticainide.Ion channel modulators as potential positive inotropic compound for treatment of heart failure.Inhibition of the sodium pump by cardioactive DPI 201-106Reversal of the cardiotonic and action-potential prolonging effects of DPI 201-106 by BDF 8784, a methyl-indol derivative.Characterization of the effects of the new inotropic agent BDF 9148 in isolated papillary muscles and myocytes of the guinea-pig heart.Very high affinity interaction of DPI 201-106 and BDF 8784 enantiomers with the phenylalkylamine-sensitive Ca2(+)-channel in Drosophila head membranes.Inotropic and electrophysiological effects of BDF 9148, a congener of DPI 201-106, in guinea-pig atria and papillary muscles.Inhibition of the myocardial Ca(2+)-current (ICa) by the enantiomers of DPI 201-106 and BDF 8784Effects of BDF 9198 on action potentials and ionic currents from guinea-pig isolated ventricular myocytes.Sodium channel enhancer restores baroreflex sensitivity in conscious dogs with heart failure.
P2860
Q34133552-A92C70CB-E640-4B98-81AD-C0B2923CB1DCQ34417019-53C1FBE6-1988-42A8-976E-59DBCFA72C77Q34594764-76C4E14B-3FEB-4BE4-8F13-502E64284DA3Q35592886-B79AD98A-C069-459C-83C9-6F45A747DC20Q35592946-569C2699-6A83-402C-9FFB-5A3E624562F8Q35755296-5E4362EF-4AF7-4B76-950A-BCDA4CADA53EQ35756330-E1F57EC5-7EE0-47B7-A28F-9B42792675ADQ35756777-FC50B98D-8BAF-4B8A-9FF3-F13B64E06A5EQ35887277-273ACAC3-3862-425D-9757-F37A9B32D1EFQ36434208-7BAF53C0-6247-4A8E-87D9-63E6EB975386Q36616392-8F5A6BC8-F701-4CA8-8A11-B8797AFAD659Q39527321-3E72EB81-0E39-4E71-A394-E88B9B2D0044Q40607760-9AE1F13F-22EF-46BA-AFE6-BD9CD84D994FQ41832319-ED1C6DAE-C96A-4DE7-A077-710EF9505D3DQ41947612-3AF7651C-59A3-43BD-B442-B4D38A071192Q42059633-2534FC63-420F-441F-A528-DA8315F7EA89Q42237253-D66441B1-2A53-49A1-B949-CC993B602F07Q42253213-A6FD3CAB-9373-491D-B027-298DBCD401E6Q42710881-A04A6018-12A2-4EFF-B9D3-B7D00546D83FQ43264586-4199C117-8485-41FE-A7D1-021ED3289D76Q45162576-F9E1BC2D-CCD2-4E06-A5CD-6FC85BAC35FA
P2860
DPI 201-106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@en
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@nl
type
label
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@en
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@nl
prefLabel
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@en
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@nl
P2093
P356
P1476
DPI 201-106, a novel cardioact ...... coronary dilatory properties.
@en
P2093
G Scholtysik
J W Herzig
R Berthold
R Markstein
R Salzmann
P2888
P304
P356
10.1007/BF00501887
P577
1985-05-01T00:00:00Z