Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.
about
Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 proteinA neuronal function of the tumor suppressor protein merlinSchwannomin isoform-1 interacts with syntenin via PDZ domainsSerine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppressionMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalMolecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsPhosphorylation of merlin regulates its stability and tumor suppressive activity.Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells.Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase.Upregulated expression of Ezrin and invasive phenotype in malignantly transformed esophageal epithelial cellsPoint mutation in the NF2 gene of HEI-193 human schwannoma cells results in the expression of a merlin isoform with attenuated growth suppressive activity.Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-LMolecular insights into NF2/Merlin tumor suppressor function.Clinical and molecular predictors of mortality in neurofibromatosis 2: a UK national analysis of 1192 patients.Merlin sumoylation is required for its tumor suppressor activity.The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells.Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma.Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation.
P2860
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P2860
Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
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name
Interaction between two isofor ...... ion of ERM proteins by merlin.
@en
Interaction between two isofor ...... ion of ERM proteins by merlin.
@nl
type
label
Interaction between two isofor ...... ion of ERM proteins by merlin.
@en
Interaction between two isofor ...... ion of ERM proteins by merlin.
@nl
prefLabel
Interaction between two isofor ...... ion of ERM proteins by merlin.
@en
Interaction between two isofor ...... ion of ERM proteins by merlin.
@nl
P2093
P2860
P1476
Interaction between two isofor ...... ion of ERM proteins by merlin.
@en
P2093
Bashour AM
P2860
P304
P356
10.1002/1097-4547(20001115)62:4<491::AID-JNR3>3.0.CO;2-D
P577
2000-11-01T00:00:00Z