Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.
about
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 moduleIdentification of cardiovascular lineage descendants at single-cell resolution.An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.Developmental origin and lineage plasticity of endogenous cardiac stem cellsCardiac deletion of Smyd2 is dispensable for mouse heart developmentNkx2.5/Csx represses myofibroblast differentiationTargeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethalityNkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardiumNKX2-5, a modifier of skeletal muscle pathology due to RNA toxicity.Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia.Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes.Bladder inflammatory transcriptome in response to tachykinins: neurokinin 1 receptor-dependent genes and transcription regulatory elementsSpecific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus.Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitorsInducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouseNkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation.Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.Cardiac cell lineages that form the heart.Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field.Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality.An early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthoodER71 directs mesodermal fate decisions during embryogenesisRe-employment of developmental transcription factors in adult heart diseaseA common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinomaSequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during CardiogenesisPartitioning the heart: mechanisms of cardiac septation and valve developmentEvolutionary conservation of Nkx2.5 autoregulation in the second heart field.Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function.Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development.Origins and fates of cardiovascular progenitor cells.Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity.Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number.
P2860
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P2860
Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Efficient Cre-mediated deletio ...... e of the homeobox gene Nkx2-5.
@en
Efficient Cre-mediated deletio ...... e of the homeobox gene Nkx2-5.
@nl
type
label
Efficient Cre-mediated deletio ...... e of the homeobox gene Nkx2-5.
@en
Efficient Cre-mediated deletio ...... e of the homeobox gene Nkx2-5.
@nl
prefLabel
Efficient Cre-mediated deletio ...... e of the homeobox gene Nkx2-5.
@en
Efficient Cre-mediated deletio ...... e of the homeobox gene Nkx2-5.
@nl
P2093
P1476
Efficient Cre-mediated deletio ...... le of the homeobox gene Nkx2-5
@en
P2093
Andrew Elefanty
Christine Biben
Edouard G Stanley
Frank Koentgen
Lorraine Robb
Louise Barnett
Richard P Harvey
P304
P577
2002-01-01T00:00:00Z