Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine.
about
DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysisEukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseasesA Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractionsEndocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed.Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta.ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx.Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors.Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifactPhospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.Protein kinase C delta mediated cytotoxicity of 6-Hydroxydopamine via sustained extracellular signal-regulated kinase 1/2 activation in PC12 cells.Analysis of rotavirus nonstructural protein NSP5 phosphorylation.Protein kinase Ctheta activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line.Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes.The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.Fibroblast fiber contraction: role of C and Rho kinase in activation by thromboxane A2.Regulation of mTOR and S6K1 activation by the nPKC isoforms, PKCepsilon and PKCdelta, in adult cardiac muscle cells.A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil.Reversible covalent inhibition of eEF-2K by carbonitriles.The second phase activation of protein kinase C delta at late G1 is required for DNA synthesis in serum-induced cell cycle progression.Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen.Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells.
P2860
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P2860
Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@en
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@nl
type
label
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@en
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@nl
prefLabel
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@en
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@nl
P2093
P2860
P1433
P1476
Elongation factor-2 kinase: ef ...... itivity towards staurosporine.
@en
P2093
P2860
P356
10.1016/0014-5793(94)80121-5
P407
P577
1994-01-01T00:00:00Z