Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3.
about
Major facilitator superfamilyEnergy coupling mechanisms of MFS transportersA structured loop modulates coupling between the substrate-binding and dimerization domains in the multidrug resistance transporter EmrE.Distribution of tetracycline resistance genes and transposons among phylloplane bacteria in Michigan apple orchardsFunctional importance and local environments of the cysteines in the tetracycline resistance protein encoded by plasmid pBR322.Conserved cytoplasmic loops are important for both the transport and chemotaxis functions of PcaK, a protein from Pseudomonas putida with 12 membrane-spanning regionsThe putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues.SV2 regulates neurotransmitter release via multiple mechanisms.Site-directed mutagenesis studies of selected motif and charged residues and of cysteines of the multifunctional tetracycline efflux protein Tet(L).Tet(L) and tet(K) tetracycline-divalent metal/H+ antiporters: characterization of multiple catalytic modes and a mutagenesis approach to differences in their efflux substrate and coupling ion preferences.Fe(2+)-tetracycline-mediated cleavage of the Tn10 tetracycline efflux protein TetA reveals a substrate binding site near glutamine 225 in transmembrane helix 7.Structural model for 12-helix transporters belonging to the major facilitator superfamily.Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter familyRole of conserved residues in hydrophilic loop 8-9 of the lactose permeaseGlutamate residues located within putative transmembrane helices are essential for TetA(P)-mediated tetracycline efflux.Sequence of a class E tetracycline resistance gene from Escherichia coli and comparison of related tetracycline efflux proteins.Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121.Protonation drives the conformational switch in the multidrug transporter LmrP.Proton-dependent multidrug efflux systems.A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter.Genetic analysis suggests functional interactions between the N- and C-terminal domains of the TetA(C) efflux pump encoded by pBR322.bmr3, a third multidrug transporter gene of Bacillus subtilis.Nucleotide and deduced protein sequences of the class D tetracycline resistance determinant: relationship to other antimicrobial transport proteins.Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump.
P2860
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P2860
Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@en
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@nl
type
label
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@en
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@nl
prefLabel
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@en
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@nl
P2093
P1476
Metal-tetracycline/H+ antiport ...... loop between helices 2 and 3.
@en
P2093
P304
19155-19162
P407
P577
1992-09-01T00:00:00Z