Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
about
Structure and mechanism of action of tau aggregation inhibitors.Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.MOST: most-similar ligand based approach to target prediction.Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors.Hybrids: a new paradigm to treat Alzheimer's disease.Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer's Disease.Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer's Disease.Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.Multiple Ligands Targeting Cholinesterases and β-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore.Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation.Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-β (Aβ)42 peptides.A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging.Fluorescent dye ProteoStat to detect and discriminate intracellular amyloid-like aggregates in Escherichia coli.6-Methyluracil derivatives as acetylcholinesterase inhibitors for treatment of Alzheimer's disease.6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice
P2860
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P2860
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
Synthesis and multitarget biol ...... difying anti-Alzheimer agents.
@en
Synthesis and multitarget biol ...... difying anti-Alzheimer agents.
@nl
type
label
Synthesis and multitarget biol ...... difying anti-Alzheimer agents.
@en
Synthesis and multitarget biol ...... difying anti-Alzheimer agents.
@nl
prefLabel
Synthesis and multitarget biol ...... difying anti-Alzheimer agents.
@en
Synthesis and multitarget biol ...... difying anti-Alzheimer agents.
@nl
P2093
P50
P356
P1476
Synthesis and multitarget biol ...... odifying anti-Alzheimer agents
@en
P2093
Angela De Simone
Belén Pérez
Cheril Tapia-Rojas
Elisabet Viayna
F Javier Luque
Irene Sola
M Victòria Clos
Nibaldo C Inestrosa
P304
P356
10.1021/JM401824W
P407
P50
P577
2014-03-10T00:00:00Z