about
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityA role for cryptochromes in sleep regulationDual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor aloneGene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleepThe Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.Identification of a population of sleep-active cerebral cortex neuronsThe hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.What rest in flies can tell us about sleep in mammals.Discovery of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia.Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems.Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor.Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor.Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.The Neurobiology of Sleep and WakefulnessNew developments in sleep research: molecular genetics, gene expression, and systems neurobiologyHomeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neuronsSleep-active cells in the cerebral cortex and their role in slow-wave activityThe wake-promoting effects of hypocretin-1 are attenuated in old rats.Cortical nNOS neurons co-express the NK1 receptor and are depolarized by Substance P in multiple mammalian species.Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms.Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsySelective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice.The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in ratsUnderstanding the sleep-wake cycle: sleep, insomnia, and the orexin system.Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip study.Challenges in the development of therapeutics for narcolepsy.Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.Prostaglandin E2 levels in cerebrospinal fluid of normal and narcoleptic dogs.Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep.Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep.Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain.Immune response gene expression increases in the aging murine hippocampus.Sleepy dogs don't lie: a genetic disorder informative about sleep.Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6/2 mouse model of Huntington's disease.A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thomas S Kilduff
@nl
Thomas S Kilduff
@sl
Thomas S. Kilduff
@en
Thomas S. Kilduff
@es
type
label
Thomas S Kilduff
@nl
Thomas S Kilduff
@sl
Thomas S. Kilduff
@en
Thomas S. Kilduff
@es
prefLabel
Thomas S Kilduff
@nl
Thomas S Kilduff
@sl
Thomas S. Kilduff
@en
Thomas S. Kilduff
@es
P106
P1153
57189668051
P21
P31
P496
0000-0002-6823-0094