Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.
about
Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistanceThe use of cephalosporins for gonorrhea: the impending problem of resistanceAntimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and futureResistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding ProteinsPenicillin-binding proteins and bacterial resistance to beta-lactamsPenicillin-binding proteins and beta-lactam resistanceHigh-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strainsMultidrug-resistant strains of Neisseria gonorrhoeae in Greece.Identification and analysis of amino acid mutations in porin IB that mediate intermediate-level resistance to penicillin and tetracycline in Neisseria gonorrhoeae.Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.Cephalosporin Resistance in Neisseria gonorrhoeae.Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime.Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeaeStructural effect of the Asp345a insertion in penicillin-binding protein 2 from penicillin-resistant strains of Neisseria gonorrhoeae.Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae.Diffusion of antibiotics through the PilQ secretin in Neisseria gonorrhoeae occurs through the immature, sodium dodecyl sulfate-labile form.Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faeciumCephalosporins in clinical development.A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeaeInterspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation.Rapid detection of the mosaic structure of the Neisseria gonorrhoeae penA Gene, which is associated with decreased susceptibilities to oral cephalosporins.Neisseria meningitidis intermediately resistant to penicillin and causing invasive disease in South Africa in 2001 to 2005.Emerging cephalosporins.Development of new drugs for an old target: the penicillin binding proteins.Penicillin-binding protein 2b of Streptococcus pneumoniae in piperacillin-resistant laboratory mutants.Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae.Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone.Point mutations of two arginine residues in the Streptomyces R61 DD-peptidase.The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability.Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis.
P2860
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P2860
Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh-hant
name
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@en
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@nl
type
label
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@en
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@nl
prefLabel
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@en
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@nl
P2093
P2860
P1476
Insertion of an extra amino ac ...... ains of Neisseria gonorrhoeae.
@en
P2093
Brannigan JA
Tirodimos IA
P2860
P304
P356
10.1111/J.1365-2958.1990.TB00664.X
P407
P577
1990-06-01T00:00:00Z