Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

Item
http://www.wikidata.org/entity/Q54416763
Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system.Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.The pathogenesis of mixed-lineage leukemia.Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia.Pontin is a critical regulator for AML1-ETO-induced leukemia.The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts.Pushing the limits: defeating leukemia stem cells by depleting telomerase.Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations.Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.Biological and clinical implications of telomere dysfunction in myeloid malignancies.Combinatorial molecular marker assays of WT1, survivin, and TERT at initial diagnosis of adult acute myeloid leukemia.
P2860

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

Item
http://www.wikidata.org/entity/Q54416763
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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2010年學術文章
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name
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@en
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@nl
type
label
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@en
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@nl
prefLabel
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@en
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P356
P1433
P1476
Leukemic fusion genes MLL/AF4 ...... f the telomerase subunit TERT.
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921