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Structural basis for engagement by complement factor H of C3b on a self surfaceAssociation of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndromeStructure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variationsExtended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implicationsGenetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcomeStructural and functional characterization of the product of disease-related factor H gene conversionStructural basis for sialic acid-mediated self-recognition by complement factor HMutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohortThe binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome.Does complement factor B have a role in the pathogenesis of atypical HUS?Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue.Membrane cofactor protein and factor I: mutations and transplantation.Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome.Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome.Atypical haemolytic uraemic syndrome.The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation.Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome.Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome.Complement regulatory genes and hemolytic uremic syndromes.Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degenUpdate on evaluating complement in hemolytic uremic syndrome.Advances in understanding of pathogenesis of aHUS and HELLP.Genetics and complement in atypical HUS.Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1).Transplantation in atypical hemolytic uremic syndrome.Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome.Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome.Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?Complement therapy in atypical haemolytic uraemic syndrome (aHUS).Thrombotic microangiopathy associated with interferon betaAutoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.Protecting the kidney from complement: atypical haemolytic uraemic syndrome.Atypical aHUS: State of the art.A national specialized service in England for atypical haemolytic uraemic syndrome-the first year's experience.The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathiesEculizumab in children with hemolytic uremic syndrome.
P50
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description
researcher ORCID: 0000-0003-4718-0072
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wetenschapper
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name
David Kavanagh
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David Kavanagh
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David Kavanagh
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David Kavanagh
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David Kavanagh
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type
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David Kavanagh
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David Kavanagh
@en
David Kavanagh
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David Kavanagh
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David Kavanagh
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prefLabel
David Kavanagh
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David Kavanagh
@en
David Kavanagh
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David Kavanagh
@nl
David Kavanagh
@sl
P106
P21
P31
P496
0000-0003-4718-0072