Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
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Systems approach to investigating host-pathogen interactions in infections with the biothreat agent Francisella. Constraints-based model of Francisella tularensisFeoB-mediated uptake of iron by Francisella tularensisDifferential chitinase activity and production within Francisella species, subspecies, and subpopulationsA Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.RipA, a cytoplasmic membrane protein conserved among Francisella species, is required for intracellular survivalGlobal transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis.Environmental and intracellular regulation of Francisella tularensis ripAIdentification and characterization of novel and potent transcription promoters of Francisella tularensis.EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice.The RNA chaperone Hfq is important for growth and stress tolerance in Francisella novicida.Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence.Construction of a bioluminescence reporter plasmid for Francisella tularensisPlasmid addiction systems: perspectives and applications in biotechnology.A Francisella tularensis live vaccine strain (LVS) mutant with a deletion in capB, encoding a putative capsular biosynthesis protein, is significantly more attenuated than LVS yet induces potent protective immunity in mice against F. tularensis chalA two-component Kdo hydrolase in the inner membrane of Francisella novicida.Utilization of an unstable plasmid and the I-SceI endonuclease to generate routine markerless deletion mutants in Francisella tularensis.Regulation of francisella tularensis virulence.Extragenic suppressor mutations in ΔripA disrupt stability and function of LpxA.The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS.Atomic structure of T6SS reveals interlaced array essential to functionRevisiting the Gram-negative lipoprotein paradigm.The acid phosphatase AcpA is secreted in vitro and in macrophages by Francisella spp.Francisella tularensis RipA protein topology and identification of functional domains.Genome-wide identification of Francisella tularensis virulence determinantsDevelopment of novel plasmid vectors and a promoter trap system in Francisella tularensis compatible with the pFLN10 based plasmids.Francisella tularensis tmRNA system mutants are vulnerable to stress, avirulent in mice, and provide effective immune protectionIdentification of Genome-Wide Mutations in Ciprofloxacin-Resistant F. tularensis LVS Using Whole Genome Tiling Arrays and Next Generation SequencingGenetic engineering of Francisella tularensis LVS for use as a novel live vaccine platform against Pseudomonas aeruginosa infections.Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophagesCharacterization and application of a glucose-repressible promoter in Francisella tularensisType IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence.The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system.The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host.Genetic dissection of the Francisella novicida restriction barrier.Improved shuttle vectors for Francisella tularensis genetics.IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A Francisella tularensisCharacterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes.Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development.Genetic manipulation of francisella tularensis.Identification of differentially regulated francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system.
P2860
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P2860
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
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2006年學術文章
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name
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@en
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@nl
type
label
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@en
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@nl
prefLabel
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@en
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@nl
P2093
P356
P1433
P1476
Genetic tools for highly pathogenic Francisella tularensis subsp. tularensis.
@en
P2093
Eric D LoVullo
Lani A Sherrill
Lanyn L Perez
Martin S Pavelka
P304
P356
10.1099/MIC.0.29121-0
P577
2006-11-01T00:00:00Z