Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
about
Structure and function of Gab2 and its role in cancer (Review)Signal transduction in the chronic leukemias: implications for targeted therapiesBiosensors in clinical practice: focus on oncohematology.Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) InterfaceElevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levelsSemi-supervised prediction of SH2-peptide interactions from imbalanced high-throughput data.Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2.Grb2-associated binder 2 silencing impairs growth and migration of H1975 cells via modulation of PI3K-Akt signaling.Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Grb2-associated binder-2 gene promotes migration of non-small cell lung cancer cells via Akt signaling pathway.The chimeric ubiquitin ligase SH2-U-box inhibits the growth of imatinib-sensitive and resistant CML by targeting the native and T315I-mutant BCR-ABLThe role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development.Broader implications of SILAC-based proteomics for dissecting signaling dynamics in cancer.Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cellsQuantitative Proteomics Analysis of Leukemia Cells.The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells.BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines.Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis.BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines.Epigenetic regulation of HOTAIR in advanced chronic myeloid leukemia
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P2860
Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
Gab2 signaling in chronic myel ...... o multiple Bcr-Abl inhibitors.
@en
Gab2 signaling in chronic myel ...... o multiple Bcr-Abl inhibitors.
@nl
type
label
Gab2 signaling in chronic myel ...... o multiple Bcr-Abl inhibitors.
@en
Gab2 signaling in chronic myel ...... o multiple Bcr-Abl inhibitors.
@nl
prefLabel
Gab2 signaling in chronic myel ...... o multiple Bcr-Abl inhibitors.
@en
Gab2 signaling in chronic myel ...... o multiple Bcr-Abl inhibitors.
@nl
P2093
P2860
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Gab2 signaling in chronic myel ...... to multiple Bcr-Abl inhibitors
@en
P2093
C F Waller
D Schramek
F U Wöhrle
J M Penninger
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P2888
P304
P356
10.1038/LEU.2012.222
P577
2012-08-03T00:00:00Z