Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
about
Cathepsin H is an additional convertase of pro-granzyme BGranzymes: a family of lymphocyte granule serine proteasesDirect cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentationA quarter century of granzymesPerforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysmGranulysin-mediated tumor rejection in transgenic miceGranzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibitionGraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences.Visualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme BFunctional classification of memory CD8(+) T cells by CX3CR1 expression.Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastaseCrystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residueThe adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicityGranzyme M mediates a novel form of perforin-dependent cell deathInterferon-alpha subtype 11 activates NK cells and enables control of retroviral infectionSerglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storageDecreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient miceGranzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus.CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisCytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosisPerforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.Definition and redesign of the extended substrate specificity of granzyme B.Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity.A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell functionTreatment of post-transfusion graft-versus-host disease with nafmostat mesilate, a serine protease inhibitor.Target cell-induced apoptosis in IL-2-activated human natural killer cells.Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cellsRegulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.NK cells and apoptosis.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected miceEctopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice.Alloprimed CD8(+) T cells regulate alloantibody and eliminate alloprimed B cells through perforin- and FasL-dependent mechanisms.A role for perforin in downregulating T-cell responses during chronic viral infection.The central and multiple roles of B cells in lupus pathogenesis.Apoptosis: the germs of death.
P2860
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P2860
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@en
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@nl
type
label
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@en
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@nl
prefLabel
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@en
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@nl
P2093
P1433
P1476
Cytotoxic lymphocytes require ...... is in allogeneic target cells.
@en
P2093
Wesselschmidt RL
P304
P356
10.1016/0092-8674(94)90376-X
P407
P577
1994-03-01T00:00:00Z