PI3K signalling: the path to discovery and understanding.
about
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.PI3K and AKT: Unfaithful Partners in CancerOphthalmic Alterations in the Sturge-Weber Syndrome, Klippel-Trenaunay Syndrome, and the Phakomatosis Pigmentovascularis: An Independent Group of Conditions?Macrophage Expression of Inflammatory Genes in Response to EMCV InfectionTargeting Protein Kinase C Downstream of Growth Factor and Adhesion SignallingWIPI-Mediated Autophagy and LongevityPerspectives in PDK1 evolution: insights from photosynthetic and non-photosynthetic organismsRegulation of mTORC1 by PI3K signalingPtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanismPhosphoinositides: tiny lipids with giant impact on cell regulationSubcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disordersPhosphoinositides: Key modulators of energy metabolismLipid kinases as therapeutic targets for chronic painPI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.A TIR domain protein from E. faecalis attenuates MyD88-mediated signaling and NF-κB activationEngineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug designInflammation induced loss of skeletal muscleA rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivoPIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical dataLymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CAPI3K at the crossroads of tumor angiogenesis signaling pathwaysIntegrin-matrix clusters form podosome-like adhesions in the absence of traction forcesThe determinants of head and neck cancer: Unmasking the PI3K pathway mutationsCharacterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinaseThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.The Emerging Role of PI3K Inhibitors in the Treatment of Hematological Malignancies: Preclinical Data and Clinical Progress to Date.Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma.PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma.Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathwaysEpidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysAMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferationPI3Kγ is a molecular switch that controls immune suppressionSodium and potassium regulate endothelial phospholipase C-γ and Bmx.Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.Screening for the protective effect target of deproteinized extract of calf blood and its mechanisms in mice with CCl4-induced acute liver injury.Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms.Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity
P2860
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P2860
PI3K signalling: the path to discovery and understanding.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
PI3K signalling: the path to discovery and understanding.
@en
PI3K signalling: the path to discovery and understanding.
@nl
type
label
PI3K signalling: the path to discovery and understanding.
@en
PI3K signalling: the path to discovery and understanding.
@nl
prefLabel
PI3K signalling: the path to discovery and understanding.
@en
PI3K signalling: the path to discovery and understanding.
@nl
P2093
P356
P1476
PI3K signalling: the path to discovery and understanding.
@en
P2093
Bart Vanhaesebroeck
Len Stephens
Phillip Hawkins
P2888
P304
P356
10.1038/NRM3290
P577
2012-02-23T00:00:00Z