Time-resolved synchrotron X-ray "footprinting", a new approach to the study of nucleic acid structure and function: application to protein-DNA interactions and RNA folding.
about
Structural mass spectrometry of proteins using hydroxyl radical based protein footprintingCoarse-grained modeling of large RNA molecules with knowledge-based potentials and structural filtersRNA misfolding and the action of chaperonesProgress and challenges for chemical probing of RNA structure inside living cellsComparison of the DNA association kinetics of the Lac repressor tetramer, its dimeric mutant LacIadi, and the native dimeric Gal repressorTertiary structure formation in the hairpin ribozyme monitored by fluorescence resonance energy transferFuture directions of structural mass spectrometry using hydroxyl radical footprinting.Classification of RNA structure change by 'gazing' at experimental data.Time-resolved NMR methods resolving ligand-induced RNA folding at atomic resolution.Cold chemical oxidation of proteins.Catching RNA polymerase in the act of binding: intermediates in transcription illuminated by synchrotron footprinting.Nucleic acid fragmentation on the millisecond timescale using a conventional X-ray rotating anode source: application to protein-DNA footprintingSAFA: semi-automated footprinting analysis software for high-throughput quantification of nucleic acid footprinting experimentsCatalytic activity as a probe of native RNA foldingFast Fenton footprinting: a laboratory-based method for the time-resolved analysis of DNA, RNA and proteinsMg2+-induced compaction of single RNA molecules monitored by tethered particle microscopyA new method to monitor the rate of conformational transitions in RNA.Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterialsStudies of biomolecular conformations and conformational dynamics by mass spectrometry.Mg2+-RNA interaction free energies and their relationship to the folding of RNA tertiary structures.Structural analysis of RNA in living cells by in vivo synchrotron X-ray footprinting.Structure-function analysis from the outside in: long-range tertiary contacts in RNA exhibit distinct catalytic roles.Distinct contribution of electrostatics, initial conformational ensemble, and macromolecular stability in RNA folding.Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3DCommunication between RNA folding domains revealed by folding of circularly permuted ribozymes.SOLEIL shining on the solution-state structure of biomacromolecules by synchrotron X-ray footprinting at the Metrology beamline.An optimal Mg(2+) concentration for kinetic folding of the tetrahymena ribozyme.High-throughput single-nucleotide structural mapping by capillary automated footprinting analysis.Folding of a universal ribozyme: the ribonuclease P RNA.The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformationsQuantitative studies of ribosome conformational dynamics.Local kinetic measures of macromolecular structure reveal partitioning among multiple parallel pathways from the earliest steps in the folding of a large RNA molecule.Energy barriers, pathways, and dynamics during folding of large, multidomain RNAs.Complementing global measures of RNA folding with local reports of backbone solvent accessibility by time resolved hydroxyl radical footprinting.Synchrotron X-ray footprinting on tour.Urea destabilizes RNA by forming stacking interactions and multiple hydrogen bonds with nucleic acid bases.Semi-automated, single-band peak-fitting analysis of hydroxyl radical nucleic acid footprint autoradiograms for the quantitative analysis of transitions.Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery.Bridging the gap between in vitro and in vivo RNA folding.Outrunning free radicals in room-temperature macromolecular crystallography.
P2860
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P2860
Time-resolved synchrotron X-ray "footprinting", a new approach to the study of nucleic acid structure and function: application to protein-DNA interactions and RNA folding.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Time-resolved synchrotron X-ra ...... interactions and RNA folding.
@en
Time-resolved synchrotron X-ra ...... interactions and RNA folding.
@nl
type
label
Time-resolved synchrotron X-ra ...... interactions and RNA folding.
@en
Time-resolved synchrotron X-ra ...... interactions and RNA folding.
@nl
prefLabel
Time-resolved synchrotron X-ra ...... interactions and RNA folding.
@en
Time-resolved synchrotron X-ra ...... interactions and RNA folding.
@nl
P2093
P356
P1476
Time-resolved synchrotron X-ra ...... A interactions and RNA folding
@en
P2093
Brenowitz M
Sullivan M
P304
P356
10.1006/JMBI.1996.0775
P407
P577
1997-02-01T00:00:00Z