Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
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Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomesMechanisms of acetaminophen-induced liver necrosisAcetylcysteine for acetaminophen poisoningN-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophenAntimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensisFree-radical metabolites of acetaminophen and a dimethylated derivativeSelective protein arylation and acetaminophen-induced hepatotoxicity.N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and miceApplication of pharmacokinetic principles in the extrapolation of animal data to humans.Analysis of the glutathione conjugate of paracetamol in human liver microsomal fraction by liquid chromatography mass spectrometry.Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury.Animal models of acute hepatic failure.Drug-induced liver injury in older adults.Intestinal metabolism of ethinyloestradiol and paracetamol in vitro: studies using Ussing chambers.Effects of microsomal enzyme induction on paracetamol metabolism in manEffects of induction of cytochrome P-450 enzymes on the concentration of foreign compounds and their metabolites and on the toxicological effects of these compounds.Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man.Drug metabolising activity of freshly isolated human hepatocytes.The role of biotransformation in chemical-induced liver injury.Reactive metabolites of phenacetin and acetaminophen: a review.Age-related changes in the hepatic pharmacology and toxicology of paracetamol.Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivoLiposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen.Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition.Hepatoprotective effect of ethanolic extract of Trichosanthes lobata on paracetamol-induced liver toxicity in rats.Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?ParacetamolRedox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in MiceThe neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes.Synergistic hepatoprotective potential of ethanolic extract of Solanum xanthocarpum and Juniperus communis against paracetamol and azithromycin induced liver injury in rats.Antioxidant and Hepatoprotective Potential of Phenol-Rich Fraction of Juniperus communis Linn. LeavesAcetaminophen and acetylcysteine dose and duration: past, present and future.Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.Ideal Experimental Rat Models for Liver DiseasesBioprinted 3D vascularized tissue model for drug toxicity analysis.Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes.Animal studies--a theoretical basis for treatment.Protective effect of fucoidan against acetaminophen-induced liver injury.Basic concepts in drug metabolism: Part II.
P2860
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P2860
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
description
1974 nî lūn-bûn
@nan
1974年の論文
@ja
1974年学术文章
@wuu
1974年学术文章
@zh-cn
1974年学术文章
@zh-hans
1974年学术文章
@zh-my
1974年学术文章
@zh-sg
1974年學術文章
@yue
1974年學術文章
@zh
1974年學術文章
@zh-hant
name
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@en
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@nl
type
label
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@en
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@nl
prefLabel
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@en
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@nl
P2093
P356
P1433
P1476
Acetaminophen-induced hepatic ...... ntoxic doses of acetaminophen.
@en
P2093
D J Jollow
J R Mitchell
M Hashimoto
S S Thorgeirsson
W Z Potter
P304
P356
10.1159/000136547
P577
1974-01-01T00:00:00Z