A dual origin of the Xist gene from a protein-coding gene and a set of transposable elementsFGF4 independent derivation of trophoblast stem cells from the common voleRYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3The interplay of histone modifications - writers that readAdvances in understanding chromosome silencing by the long non-coding RNA XistConsiderations when investigating lncRNA function in vivo.Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolutionPolycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivationSmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivationEpigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomesMammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genesTranscription initiation activity sets replication origin efficiency in mammalian cellsCharacterization of the genomic Xist locus in rodents reveals conservation of overall gene structure and tandem repeats but rapid evolution of unique sequenceThree-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.Early loss of Xist RNA expression and inactive X chromosome associated chromatin modification in developing primordial germ cells.Genome Environment Browser (GEB): a dynamic browser for visualising high-throughput experimental data in the context of genome features.The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usageConstruction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses.Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy.Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosomeA Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7Chromatin sampling--an emerging perspective on targeting polycomb repressor proteinsGenome-wide shRNA screening to identify factors mediating Gata6 repression in mouse embryonic stem cells.SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaksDosage compensation in mammals.Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation.KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.Characterisation of molecular DNA rearrangements within the Xq12-q13.1 region, in three patients with X-linked hypohidrotic ectodermal dysplasia (EDA).Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain.Noncoding RNA and Polycomb recruitment.MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming.Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.
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Wellcome Trust Principal Resea ...... ry at the University of Oxford
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Neil Brockdorff
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Neil Alexander Steven Brockdorff
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1958-01-01T00:00:00Z