UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.

UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.

Item
http://www.wikidata.org/entity/Q54958021
Pyrimidine and purine analogues, effects on cell cycle regulation and the role of cell cycle inhibitors to enhance their cytotoxicity.Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo.UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery.UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein.
P2860

UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.

Item
http://www.wikidata.org/entity/Q54958021
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
UCN-01 (7-hydroxystaurosporine ...... late synthetase messenger RNA.
@en
UCN-01
@nl
type
label
UCN-01 (7-hydroxystaurosporine ...... late synthetase messenger RNA.
@en
UCN-01
@nl
prefLabel
UCN-01 (7-hydroxystaurosporine ...... late synthetase messenger RNA.
@en
UCN-01
@nl
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P1476
P2093
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P5875
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P1433
P1476
UCN-01 (7-hydroxystaurosporine ...... late synthetase messenger RNA.
@en
P2093
P2860
P304
P31
P356
10.1111/J.1349-7006.2000.TB00904.X
P433
P478
P577
P5875
P698
P921
P932