about
Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitorsA patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alphaMutational heterogeneity in cancer and the search for new cancer-associated genesMelanoma genome sequencing reveals frequent PREX2 mutationsThe genomic complexity of primary human prostate cancerDissecting the genomic complexity underlying medulloblastomaInitial genome sequencing and analysis of multiple myelomaImpact of whole genome amplification on analysis of copy number variantsGenome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibitionMapping the hallmarks of lung adenocarcinoma with massively parallel sequencingMutational evolution in a lobular breast tumour profiled at single nucleotide resolutionMedulloblastoma exome sequencing uncovers subtype-specific somatic mutationsDiscovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation.Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.VisCap: inference and visualization of germ-line copy-number variants from targeted clinical sequencing data.Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients.Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing.Landscape of genomic alterations in cervical carcinomas.Epigenomic alterations define lethal CIMP-positive ependymomas of infancyExome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.Development and validation of a computational method for assessment of missense variants in hypertrophic cardiomyopathy.WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastomaIntegrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomasOligonucleotide microarray analysis of genomic imbalance in children with mental retardationA shower of second hit events as the cause of multifocal renal cell carcinoma in tuberous sclerosis complex.Oncotator: cancer variant annotation tool.Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.Data resources for the identification and interpretation of actionable mutations by clinicians.Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.A BAC clone fingerprinting approach to the detection of human genome rearrangementsRelapsed neuroblastomas show frequent RAS-MAPK pathway mutationsNext generation sequencing-based copy number analysis reveals low prevalence of deletions and duplications in 46 genes associated with genetic cardiomyopathies.The genetic landscape of high-risk neuroblastoma.Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.Divergent clonal selection dominates medulloblastoma at recurrenceInhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinomaGenomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusionNoncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.Institutional implementation of clinical tumor profiling on an unselected cancer population.
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P50
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onderzoeker
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հետազոտող
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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Trevor J Pugh
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P106
P31
P496
0000-0002-8073-5888