about
Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 systemMinimizing off-Target Mutagenesis Risks Caused by Programmable NucleasesEfficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitroConstitutive heterochromatin reorganization during somatic cell reprogrammingTargeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis.MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapyFocal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS miceIsolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states.Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neuronsGenome Editing Gene Therapy for Duchenne Muscular Dystrophy.Genetic correction using engineered nucleases for gene therapy applications.From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing.Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma DevelopmentSall1 transiently marks undifferentiated heart precursors and regulates their fateCartilage tissue engineering identifies abnormal human induced pluripotent stem cells.Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy.Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch.Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate.Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency.Retrovirus silencing by an epigenetic TRIM.The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type.Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells.Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model.Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells.Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae.EOS lentiviral vector selection system for human induced pluripotent stem cells.Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells.Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress.A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production[Advances in genome editing technologies for treating muscular dystrophy.]Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skippingA patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Akitsu Hotta
@ast
Akitsu Hotta
@en
Akitsu Hotta
@es
Akitsu Hotta
@nl
Akitsu Hotta
@sl
type
label
Akitsu Hotta
@ast
Akitsu Hotta
@en
Akitsu Hotta
@es
Akitsu Hotta
@nl
Akitsu Hotta
@sl
prefLabel
Akitsu Hotta
@ast
Akitsu Hotta
@en
Akitsu Hotta
@es
Akitsu Hotta
@nl
Akitsu Hotta
@sl
P106
P31
P496
0000-0002-2619-7441