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Identification of hepatoprotective flavonolignans from silymarinCytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the BionectriaceaeEthanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic BacteriaA mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibitionStructural insights into sulfite oxidase deficiency.Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.Physiologically based pharmacokinetic modeling framework for quantitative prediction of an herb-drug interaction.Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study.Bioactive constituents of the stem bark of Mitrephora glabra.Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationshipsIdentification of neuropeptide S antagonists: structure-activity relationship studies, X-ray crystallography, and in vivo evaluation.Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation.Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica).Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis)Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides.Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.Enhanced bioactivity of silybin B methylation productsHiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin caseA validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts.Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme.A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.Multiple effects of silymarin on the hepatitis C virus lifecycle.Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).Diterpene glycosides from Egletes viscosa.Conventional and accelerated-solvent extractions of green tea (camellia sinensis) for metabolomics-based chemometrics.Synthesis of poly(1,2-glycerol carbonate)-paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer.Production and purification of N-terminal half-transferrin in Pichia pastoris.Optimization of expression of human sulfite oxidase and its molybdenum domain.
P50
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P50
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Tyler N. Graf
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Tyler N. Graf
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P31
P496
0000-0003-4145-2815