about
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTEBiomimetic synthesis and optimization of cyclic peptide antibioticsChemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules.Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent.Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.TET enzymes, TDG and the dynamics of DNA demethylation.High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.Targets for Combating the Evolution of Acquired Antibiotic ResistanceImproving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection.APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcriptionThe antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutationNucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating AntibioticsA portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase.The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.Quantification of Oxidized 5-Methylcytosine Bases and TET Enzyme Activity.Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism.The expanding scope and impact of epigenetic cytosine modifications.Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis.APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.Molecular targeting of mutagenic AID and APOBEC deaminasesSensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage.Mechanisms for targeted, purposeful mutation revealed in an APOBEC-DNA complex.Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia.Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.When to think of zebras.Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network.Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminaseOGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in developmentSelectivity and Promiscuity in TET-mediated oxidation of 5-methylcytosine in DNA and RNAAdvancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS ResponseThe oxidative half-reaction of Old Yellow Enzyme. The role of tyrosine 196Grand challenge commentary: The chemistry of a dynamic genomeMolecular biology. Demystifying DNA demethylationIntroduction: Genome Modifying Mechanisms
P50
Q27638960-C1EE6E7C-A1AB-4970-ABAA-835C8686730CQ28217202-5F25DEBB-C32B-442F-BDC5-E7260EC5AF25Q33187336-E1D8DA4C-07BD-4E98-B2E1-98560680E65CQ33209167-12E5ABCB-E834-42C2-B0DF-1047B6306A13Q33650603-06B78896-590D-46A2-A10F-08424F5A6600Q33715010-1662181B-CC9E-4AF0-A20D-A3F1304C72DAQ34115490-4A9203A3-487F-4E08-8BF3-7EB737BECD78Q34412763-B2E862D7-3484-4DF7-A8AF-4981921DA081Q35754447-BB3418D0-CE44-4B58-B67B-9980C3B70C55Q36342994-6261EAEB-6364-42D7-B0D3-D1C28291BEB1Q36759909-25C956A3-344E-4FA8-8D6A-7D5F32D39A6EQ36968375-25066C14-BF40-492A-8CDB-5BD1FF115139Q37143544-526C48BC-B9C2-42E8-BC03-362F78837BF9Q37166834-6E18A481-CBA4-4854-9AF2-276B417734ADQ37371679-FA1F14A9-CC2E-403C-B82B-E19B78A909F2Q37946460-1CCC9C54-9B35-4DFD-9724-2D8FEEAF1F12Q38291835-CD303846-32B8-4CC8-B311-AB766FE0B1A7Q38587746-39B085A3-3EDA-4A36-93B4-5D0D6D1ED6BFQ38868484-5873816F-DF7F-4010-9F8D-5BCD2F922415Q39867010-CD284F6A-F238-4E9B-A86E-57E78A2CF733Q41510570-CD1CC5D3-19D3-4D9D-9055-46311A4E7072Q41917830-4258C7BB-9CB0-48FC-BFE3-70184D69AD24Q42725143-9B37DF2E-BE6A-4A2E-8E12-F8133086B94AQ43222262-AB77C8F9-6D28-4CF1-B0EE-19C0DFA20AAFQ45059780-692294AA-9604-41C2-BA43-8A41E79B2A7DQ47145902-8174607B-B079-42DF-9451-474C9C167F6AQ47587699-938890C9-182B-4E95-B89B-ACED35B59E35Q48180112-F8ED0273-088B-4CA3-9097-35693FD87517Q48296470-1073D93A-9C46-4EE9-8EAA-3BE2CA2B1602Q48350953-EE30F08B-594B-45A3-91E2-9ED5C16AF6E2Q48655604-F242373D-690F-4452-8111-F8F0FC4EA32BQ55193696-8573D4F1-1C5A-4D45-A051-C2221F6B36D5Q57181747-88D8C66F-6B2E-43E0-8564-DEB6AA0E81B1Q57456942-DD4C98DA-0DFD-4560-9EFB-D8AE55256968Q58615492-0F4485F4-E162-4DA4-831B-B2F6E99D63FEQ60949764-9B3A90EB-58B4-4AF9-8040-0138DA53A610Q77604550-C14BEBFB-ADA0-4A03-B7C4-1967B639A84DQ82463891-BA768950-003F-4819-81CB-934D72CA6C93Q84874981-30B907EF-BE73-427B-8A71-20D8742B5DE1Q88624215-97CB31C9-0F90-4BB5-92FF-BD76BFDE192E
P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Rahul M. Kohli
@ast
Rahul M. Kohli
@en
Rahul M. Kohli
@es
Rahul M. Kohli
@nl
Rahul M. Kohli
@sl
type
label
Rahul M. Kohli
@ast
Rahul M. Kohli
@en
Rahul M. Kohli
@es
Rahul M. Kohli
@nl
Rahul M. Kohli
@sl
prefLabel
Rahul M. Kohli
@ast
Rahul M. Kohli
@en
Rahul M. Kohli
@es
Rahul M. Kohli
@nl
Rahul M. Kohli
@sl
P106
P1153
7102235069
P31
P496
0000-0002-7689-5678