about
Early events in protein folding: Is there something more than hydrophobic burst?Denatured state is critical in determining the properties of model proteins designed on different folds.Low-throughput model design of protein folding inhibitors.Thermodynamic features characterizing good and bad folding sequences obtained using a simplified off-lattice protein model.Sequence of events in folding mechanism: beyond the Gō modelImprint of evolution on protein structures.The network of stabilizing contacts in proteins studied by coevolutionary data.A many-body term improves the accuracy of effective potentials based on protein coevolutionary data.Sampling the Denatured State of Polypeptides in Water, Urea, and Guanidine Chloride to Strict Equilibrium Conditions with the Help of Massively Parallel Computers.Similar folds with different stabilization mechanisms: the cases of Prion and Doppel proteins.Early events in insulin fibrillization studied by time-lapse atomic force microscopy.Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription.Insight into the folding inhibition of the HIV-1 protease by a small peptideFolding and aggregation of designed proteins.Atomistic simulations of the HIV-1 protease folding inhibition.Oscillations and temporal signalling in cells.HIV-1 protease folding and the design of drugs which do not create resistance.Urea and guanidinium chloride denature protein L in different ways in molecular dynamics simulations.Thermodynamic and structural effect of urea and guanidine chloride on the helical and on a hairpin fragment of GB1 from molecular simulations.Modelling genome-wide topological associating domains in mouse embryonic stem cells.Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs.The maturation of HIV-1 protease precursor studied by discrete molecular dynamics.Predicting the tertiary structure of a lattice designed model protein from its primary structure.The complex folding behavior of HIV-1-protease monomer revealed by optical-tweezer single-molecule experiments and molecular dynamics simulations.Understanding the determinants of stability and folding of small globular proteins from their energetics.Energy profile of the space of model protein sequencesDesign of HIV-1-PR inhibitors that do not create resistance: blocking the folding of single monomers.Design and folding of dimeric proteins.Beta-hairpin conformation of fibrillogenic peptides: structure and alpha-beta transition mechanism revealed by molecular dynamics simulations.A folding inhibitor of the HIV-1 protease.The determinants of stability in the human prion protein: insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions.Integrating experiment, theory and simulation to determine the structure and dynamics of mammalian chromosomes.The dynamics of genetic control in the cell: the good and bad of being late.Optical absorption of a green fluorescent protein variant: environment effects in a density functional study.Iterative derivation of effective potentials to sample the conformational space of proteins at atomistic scale.Ratcheted molecular-dynamics simulations identify efficiently the transition state of protein folding.Hierarchy of folding and unfolding events of protein G, CI2, and ACBP from explicit-solvent simulations.Identification of the folding inhibitors of hen-egg lysozyme: gathering the right tools.The molecular evolution of HIV-1 protease simulated at atomic detail.Metadynamic sampling of the free-energy landscapes of proteins coupled with a Monte Carlo algorithm.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Guido Tiana
@ast
Guido Tiana
@en
Guido Tiana
@es
Guido Tiana
@nl
Guido Tiana
@sl
type
label
Guido Tiana
@ast
Guido Tiana
@en
Guido Tiana
@es
Guido Tiana
@nl
Guido Tiana
@sl
prefLabel
Guido Tiana
@ast
Guido Tiana
@en
Guido Tiana
@es
Guido Tiana
@nl
Guido Tiana
@sl
P1053
E-2123-2015
P106
P1153
7003601713
P21
P31
P3829
P496
0000-0001-9868-1809