Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.

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Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

@zh

2018年学术文章

@zh-cn

2018年学术文章

@zh-hans

2018年学术文章

@zh-my

2018年学术文章

@zh-sg

2018年學術文章

@yue

2018年學術文章

@zh-hant

name

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@en

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@nl

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Item

label

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@en

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@nl

prefLabel

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@en

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@nl

P1476

Systemic overexpression of SQS ...... 6R-expressing ALS mouse model.

@en

P2093

Gen Sobue

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Hui-Fang Shang

http://www.w3.org/2001/XMLSchema#string

Kai Sato

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Masahisa Nozaki

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Masashi Aoki

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Ryohei Shirakawa

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Shun Mitsui

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Suzuka Ono

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P2860

Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

State of play in amyotrophic lateral sclerosis genetics

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

Autophagy: renovation of cells and tissues

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Onset and progression in inherited ALS determined by motor neurons and microglia

P2888

s13041-018-0373-8

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scholarly article

P356

10.1186/S13041-018-0373-8

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P433

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P478

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P50

Hiroaki Adachi

Shinji Hadano

Asako Otomo

P577

2018-05-29T00:00:00Z

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P6179

1104290394

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P698

29843805

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P921

amyotrophic lateral sclerosis

overexpression

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5975400

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