about
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseStudies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factorAsparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factorStructural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediatesFactor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domainsHydroxylation of the eukaryotic ribosomal decoding center affects translational accuracyCellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)Structures of two kinetic intermediates reveal species specificity of penicillin-binding proteinsOxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic AcidsCrystal structures of histone demethylase JMJD2A reveal basis for substrate specificityEvidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylasesAsparagine beta-hydroxylation stabilizes the ankyrin repeat domain foldStructural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylasesCrystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathwayCrystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylaseSelective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic ApproachesCrystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factorInhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl CompoundsThe oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesLinking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylasesDynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylasePlant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone DemethylasesStructure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylationRibosomal oxygenases are structurally conserved from prokaryotes to humansSubstrate selectivity analyses of factor inhibiting hypoxia-inducible factorSelective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylasesStructure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversityStructural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathwayBinding of (5S)-penicilloic acid to penicillin binding protein 3Structural insights into how 5-hydroxymethylation influences transcription factor bindingRhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibitionDisruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activityStructural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesisStructure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum diseaseStructural studies on human 2-oxoglutarate dependent oxygenasesStructural and mechanistic studies on γ-butyrobetaine hydroxylase
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
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name
Michael A McDonough
@ast
Michael A McDonough
@en
Michael A McDonough
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Michael A McDonough
@nl
Michael A McDonough
@sl
type
label
Michael A McDonough
@ast
Michael A McDonough
@en
Michael A McDonough
@es
Michael A McDonough
@nl
Michael A McDonough
@sl
prefLabel
Michael A McDonough
@ast
Michael A McDonough
@en
Michael A McDonough
@es
Michael A McDonough
@nl
Michael A McDonough
@sl
P106
P21
P31
P496
0000-0003-4664-6942