The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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High-affinity interactions and signal transduction between Aβ oligomers and TREM2 The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans An exTREMe disruption in Alzheimer's cleanup

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年學術文章

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2018年學術文章

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2018年學術文章

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

@en

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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type

Item

label

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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P1476

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

@en

P2093

Brad T Casali

http://www.w3.org/2001/XMLSchema#string

Bruce T Lamb

http://www.w3.org/2001/XMLSchema#string

Erin G Reed-Geaghan

http://www.w3.org/2001/XMLSchema#string

Gary E Landreth

http://www.w3.org/2001/XMLSchema#string

Guixiang Xu

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J Colleen Karlo

http://www.w3.org/2001/XMLSchema#string

Miguel Moutinho

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Paul J Cheng-Hathaway

http://www.w3.org/2001/XMLSchema#string

Richard M Ransohoff

http://www.w3.org/2001/XMLSchema#string

Roxanne Y Williams

http://www.w3.org/2001/XMLSchema#string

P2860

TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

Neuropathological alterations in Alzheimer disease

Neuroinflammation in Alzheimer's disease

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Aβ Extraction from Murine Brain Homogenates.

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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P2860

P2860

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.

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