about
JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cellsRegulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectorsMunc13-4 interacts with syntaxin 7 and regulates late endosomal maturation, endosomal signaling, and TLR9-initiated cellular responsesAberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiencyVesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.Upregulation of the Rab27a-dependent trafficking and secretory mechanisms improves lysosomal transport, alleviates endoplasmic reticulum stress, and reduces lysosome overload in cystinosis.JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.Munc13-4 Is a Rab11-binding Protein That Regulates Rab11-positive Vesicle Trafficking and Docking at the Plasma Membrane.MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membraneGene transfer and expression in human neutrophils. The phox homology domain of p47phox translocates to the plasma membrane but not to the membrane of mature phagosomes.Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1.The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells.Munc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophilsImpairment of chaperone-mediated autophagy leads to selective lysosomal degradation defects in the lysosomal storage disease cystinosisThe role of Rab27a in the regulation of neutrophil function.Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells.Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes.Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.Rab27a regulates GM-CSF-dependent priming of neutrophil exocytosis.Cross-talk between IRAK-4 and the NADPH oxidase.Editorial: The secrets of secretion.Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRBiochemical and morphological changes in the developing kidney.The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules.Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretionNitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescenceBradykinin stimulates phosphoinositide turnover and phospholipase C but not phospholipase D and NADPH oxidase in human neutrophilsOxidative stress in rodent closed duodenal loop pancreatitisDecreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cellsKinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophilsEvaluation of the blood components considered as risk predictors in coronary heart diseaseNeutrophils: New insights and open questionsCross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Sergio D Catz
@ast
Sergio D Catz
@en
Sergio D Catz
@es
Sergio D Catz
@nl
Sergio D Catz
@sl
type
label
Sergio D Catz
@ast
Sergio D Catz
@en
Sergio D Catz
@es
Sergio D Catz
@nl
Sergio D Catz
@sl
prefLabel
Sergio D Catz
@ast
Sergio D Catz
@en
Sergio D Catz
@es
Sergio D Catz
@nl
Sergio D Catz
@sl
P106
P108
P21
P31
P496
0000-0002-1873-0277