Inactivating KISS1 mutation and hypogonadotropic hypogonadism
about
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromesA Multi-Oscillatory Circadian System Times Female ReproductionComprehensive Review on Kisspeptin and Its Role in Reproductive DisordersThe genetic basis of female reproductive disorders: etiology and clinical testingAfferent neuronal control of type-I gonadotropin releasing hormone neurons in the humanInteractions between kisspeptins and neurokinin BThe relationship between gut and adipose hormones, and reproductionTwo families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutationOvarian regulation of kisspeptin neurones in the arcuate nucleus of the rhesus monkey (macaca mulatta)Applying gene silencing technology to contraceptionAblation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats.ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice.Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice.Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period.Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cellsPrenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in miceShift in Kiss1 cell activity requires estrogen receptor α.Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo.Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in micePRR repeats in the intracellular domain of KISS1R are important for its export to cell membrane.Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity.Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice.Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factorKisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.Twice-daily subcutaneous injection of kisspeptin-54 does not abolish menstrual cyclicity in healthy female volunteers.Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female.Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio).Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouseMinireview: Metabolic control of the reproductive physiology: insights from genetic mouse modelsIncreasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of Kisspeptin-54.Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment.Leptin signaling in Kiss1 neurons arises after pubertal developmentExogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadismChemical identity of hypothalamic neurons engaged by leptin in reproductive control.Congenital hypogonadotropic hypogonadism during childhood: presentation and genetic analyses in 46 boys.Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human.Mutations in KISS1 are not responsible for idiopathic hypogonadotropic hypogonadism in Chinese patients.
P2860
Q21131272-C1535063-3784-43FB-92D5-E5A5E61E05BBQ26779448-C0C4F2CE-43B4-403E-AFF3-82C56F12B8F6Q26801682-18DAC958-E83B-4C38-AEDD-5E64F5354025Q26865875-17341BC5-34E8-4B0A-AD33-8D9E935C6161Q27015901-9A5BD11A-C063-4116-A874-8A5F842CC7DEQ28288195-C8E89F22-885B-4C7D-9FF9-11832840F378Q28301116-40CC618F-D3CB-4542-BFE0-AEAC86158A45Q28485191-79C6ABD1-EDCE-4DF0-A0C3-A7D7E09249DEQ28658906-D18481F7-495A-4784-8C1E-4CFDE62938F5Q28703567-AF77E17F-7DA2-4C91-9F9C-48877612710BQ30352945-006509DF-8505-42EC-B7FE-A66D7F7D6C53Q30353367-2DB3990D-E922-43AA-AD05-FB87A262805AQ30360918-5C5BDD59-2484-47C4-8FF3-EB9691E80F25Q30405254-4A238022-9A95-4FAF-A73F-DC74967FB4CFQ30414505-E4A2A9DE-A35B-442C-A465-4FCA9636E591Q30417384-FFE511B2-DE04-4CA3-9AD5-10E48140E60BQ30417676-9F8A8D83-38D0-4F37-9DC0-5CF76D08026CQ30419024-1B85E081-F7EA-4DEC-94E4-68F6FDE910AFQ30419232-5156035A-15CA-43E7-9798-CF7894B85349Q33626546-2B4AA4C1-1BE9-4102-A819-67BBAAF9D0B0Q33631824-40E2C35D-FC75-4BD4-8BB2-883CE1C8F556Q33633147-18BC3D50-62E3-49F1-9CE4-FD537EC6551BQ33808252-F8771DBE-1515-4CEB-94C2-A3FEDE5029BDQ33823542-07ED16DA-3F0D-49E0-BF26-032BBD4DC321Q33901215-142592EB-3BE4-4574-AA95-8CF7F390069CQ33944146-2E61FA5F-DF84-431E-80D4-FA8D247EF781Q33953607-AEC69511-B81B-4DE6-98DA-DBA0ABE6B94FQ33977447-C69BEC8E-D49D-40AC-94BA-D586AAD94F85Q34004841-42DEF190-A1A7-47F0-9D92-AD11224702ABQ34200810-0875DDD5-27BD-4145-9A6F-334B353E4240Q34232244-5A07450B-6962-47DF-B450-D0131681706DQ34377069-91CC1F77-D331-49C7-A6E1-DDBAB1F67532Q34396440-72F79190-1E71-4D58-927B-5A7917B42EA0Q34486033-126FCD32-8710-4425-91A8-1B9971EDAAB4Q34626000-E9E621A1-1C1A-41F3-A5BB-80D404CB8E8FQ34628288-AD650071-C58E-4452-814E-68A04921A69AQ34647077-9A179F65-5F69-46D7-B75D-CC72F04901BBQ35035684-8348DA3A-2F19-473D-B2AC-447575463516Q35066723-1769ED3E-EC2C-4D31-B111-0142863848DDQ35186934-01FBBFF4-069F-4FCA-8ED1-8C5836572348
P2860
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
description
article
@en
im Februar 2012 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2012
@uk
ലേഖനം
@ml
name
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@en
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@nl
type
label
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@en
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@nl
prefLabel
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@en
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@nl
P2093
P50
P356
P1476
Inactivating KISS1 mutation and hypogonadotropic hypogonadism
@en
P2093
A Kemal Topaloglu
Fatih Temiz
Javier A Tello
M Bertan Yilmaz
Mehmet N Ozbek
P304
P356
10.1056/NEJMOA1111184
P407
P577
2012-02-01T00:00:00Z