about
S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligandsSynthesis, physical properties, toxicological studies and bioavailability of L-pyroglutamic and L-glutamic acid esters of paracetamol as potentially useful prodrugs.Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.Sigma-2 receptor ligands QSAR model dataset.(+)-Pentazocine attenuates SH-SY5Y cell death, oxidative stress and microglial migration induced by conditioned medium from activated microglia.(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury.Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors.Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties.Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.Evaluation of N-substitution in 6,7-benzomorphan compounds.New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation.Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitorsAnti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion.Specific kappa opioid receptor agonists.CCB, a novel specific kappa opioid agonist, which discriminates between opioid and sigma 1 recognition sites.Synthesis and binding affinity of cis-(-)- and cis-(+)-N-ethyleneamino-N-nordeoxymetazocine and cis-(-)-N-normetazocine analogues at sigma1, sigma2 and kappa opioid receptors.Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand.A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect.(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects.Crystal morphologies and polymorphs in tolbutamide microcrystalline powder.Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment.Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats.Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia.Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma.(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase.Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis.Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents.Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands.Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration.Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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Agostino Marrazzo
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P106
P1153
7004890342
P21
P31
P496
0000-0002-8728-8857