about
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseES cell neural differentiation reveals a substantial number of novel ESTs.High-throughput screening by RNA interference: control of two distinct types of variance.Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal agingA complex of iron and nucleic acid catabolites is a signal that triggers differentiation in a freshwater protozoanPathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing.Beyond amyloid: the next generation of Alzheimer's disease therapeutics.Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia.Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators.Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators.N-heterocyclic derived M1 positive allosteric modulators.Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators.Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.Expression of ionotropic glutamate receptor genes by P19 embryonal carcinoma cells.Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.Gene expression analyses in cynomolgus monkeys provides mechanistic insight into high-density lipoprotein-cholesterol reduction by androgens in primates.Probability of Alzheimer's disease in breast cancer survivors based on gray-matter structural network efficiency.The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase.Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells.Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture.A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1Fused heterocyclic M1 positive allosteric modulatorsDevelopment of a microplate fluorescence assay for kynurenine aminotransferaseHydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulatorsDesign, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs)MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
William J Ray
@nl
William J Ray
@sl
William J. Ray
@en
William J. Ray
@es
type
label
William J Ray
@nl
William J Ray
@sl
William J. Ray
@en
William J. Ray
@es
altLabel
William Ray
@en
prefLabel
William J Ray
@nl
William J Ray
@sl
William J. Ray
@en
William J. Ray
@es
P106
P1153
55317512000
P21
P31
P496
0000-0002-4491-167X