about
Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of InfectionMultidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthmaA deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.Viral infection of human lung macrophages increases PDL1 expression via IFNβ.Mechanisms of Hypoxic Up-Regulation of Versican Gene Expression in Macrophages.A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.RIPOSTE: a framework for improving the design and analysis of laboratory-based research.Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanismsViral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36.Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.Dysregulation of Antiviral Function of CD8(+) T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1-PD-L1 Axis.Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases.Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care recordsIFNγ Influences Epithelial Anti-viral Responses via Histone Methylation of the Rig-I Promoter.IL-12 and IL-7 synergise to control MAIT cell cytotoxic responses to bacterial infection.A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD.Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells.Novel expression of a functional trimeric fragment of human SP-A with efficacy in neutralisation of RSV.Nuclear factor-kappaB does not mediate the inhibitory effects of dexamethasone on granulocyte-macrophage colony-stimulating factor expression.Correction: Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients.IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase.Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations.Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort.Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD.Lung macrophages: old hands required rather than new blood?Reply: The PD-1-PD-L1 Axis in Chronic Obstructive Pulmonary Disease.Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.Macrophages and neutrophils: dynamic duo or partners in crime?Increased TNF expression in CD43++ murine blood monocytes.Editorial: Therapeutics for acute lung injury: time to call in the DRs?Development of flow cytometric opsonophagocytosis and antibody-mediated complement deposition assays for non-typeable Haemophilus influenzaeStimulus-Specific Inhibition of IL-5 by cAMP-Elevating Agents and IL-10 Reveals Differential Mechanisms of ActionHuman CD49a Lung Natural Killer Cell Cytotoxicity in Response to Influenza A VirusDrivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohortExpression of p57-Kip2 in monocytes and macrophages
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wetenschapper
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հետազոտող
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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Karl Staples
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P106
P31
P496
0000-0003-3844-6457