about
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptorPlatelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activityFeedback regulation of beta-arrestin1 function by extracellular signal-regulated kinasesProtein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted systemReviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptorsSrc-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptorThe beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.Regulation of tyrosine kinase cascades by G-protein-coupled receptors.A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.Beyond desensitization: physiological relevance of arrestin-dependent signaling.Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangementEpidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger.Refining efficacy: exploiting functional selectivity for drug discovery.A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane.Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors.Delineation of a conserved arrestin-biased signaling repertoire in vivo.'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activationInhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel.Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activationExploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomicsSignal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.Endocrine function in aging.Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes.β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivoRole of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.The origins of diversity and specificity in g protein-coupled receptor signalingThe conformational signature of β-arrestin2 predicts its trafficking and signalling functions.Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetesInsulin-like growth factor-2/mannose-6 phosphate receptors.Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.Diversity in arrestin function.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.
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P50
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wetenschapper
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Louis M. Luttrell
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Louis M. Luttrell
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Louis M. Luttrell
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Louis M. Luttrell
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Louis M. Luttrell
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Louis M. Luttrell
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Louis M. Luttrell
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Louis M. Luttrell
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P106
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16145195900
P31
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0000-0003-2805-6949