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Strain Prioritization and Genome Mining for Enediyne Natural ProductsFunctional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenesStrain prioritization for natural product discovery by a high-throughput real-time PCR method.Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analogEnediynes: Exploration of microbial genomics to discover new anticancer drug leads.Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins.Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026.Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027Germicidins H-J from Streptomyces sp. CB00361.Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells.Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D.Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues.Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and ExpansionBiosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.A designer bleomycin with significantly improved DNA cleavage activity.Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions.Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues.Discovery of the leinamycin family of natural products by mining actinobacterial genomes.Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234.Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.Oxidative activation of leinamycin E1 triggers alkylation of guanine residues in double-stranded DNA.Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity.Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate PromiscuitiesThe genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cellsBiochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic PathwayComparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin BiosynthesisDiscovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686
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description
researcher ORCID: 0000-0003-2917-0663
@en
name
Dong Yang
@ast
Dong Yang
@en
Dong Yang
@es
Dong Yang
@nl
Dong Yang
@sl
type
label
Dong Yang
@ast
Dong Yang
@en
Dong Yang
@es
Dong Yang
@nl
Dong Yang
@sl
prefLabel
Dong Yang
@ast
Dong Yang
@en
Dong Yang
@es
Dong Yang
@nl
Dong Yang
@sl
P106
P31
P496
0000-0003-2917-0663